Altered Gut Microbiota in a Fragile X Syndrome Mouse Model

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dc.contributor.authorAltimiras, Francisco
dc.contributor.authorGarcia, Jose Antonio
dc.contributor.authorPalacios-Garcia, Ismael
dc.contributor.authorHurley, Michael J.
dc.contributor.authorDeacon, Robert
dc.contributor.authorGonzalez, Bernardo
dc.contributor.authorCogram, Patricia
dc.date.accessioned2025-01-20T22:20:23Z
dc.date.available2025-01-20T22:20:23Z
dc.date.issued2021
dc.description.abstractThe human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neurodevelopmental disorder considered the most common cause of inherited intellectual disability and the leading monogenetic cause of autism. The role of the gut microbiome in FXS remains largely unexplored. Here, we report the results of a gut microbiome analysis using a FXS mouse model and 16S ribosomal RNA gene sequencing. We identified alterations in the fmr1 KO2 gut microbiome associated with different bacterial species, including those in the genera Akkermansia, Sutterella, Allobaculum, Bifidobacterium, Odoribacter, Turicibacter, Flexispira, Bacteroides, and Oscillospira. Several gut bacterial metabolic pathways were significantly altered in fmr1 KO2 mice, including menaquinone degradation, catechol degradation, vitamin B6 biosynthesis, fatty acid biosynthesis, and nucleotide metabolism. Several of these metabolic pathways, including catechol degradation, nucleotide metabolism and fatty acid biosynthesis, were previously reported to be altered in children and adults with autism. The present study reports a potential association of the gut microbiome with FXS, thereby opening new possibilities for exploring reliable treatments and non-invasive biomarkers.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fnins.2021.653120
dc.identifier.eissn1662-453X
dc.identifier.urihttps://doi.org/10.3389/fnins.2021.653120
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94622
dc.identifier.wosidWOS:000659516900001
dc.language.isoen
dc.revistaFrontiers in neuroscience
dc.rightsacceso restringido
dc.subjectautism spectrum disorders
dc.subjectbiomarkers
dc.subjectdrug development
dc.subjectdrug targets
dc.subjectfragile X syndrome
dc.subjectgut microbiota
dc.subjectmouse models
dc.subjectneuroinflammation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAltered Gut Microbiota in a Fragile X Syndrome Mouse Model
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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