RELB, A NEW REL FAMILY TRANSCRIPTION ACTIVATOR THAT CAN INTERACT WITH P50-NF-KAPPA-B

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dc.contributor.authorRYSECK, RP
dc.contributor.authorBULL, P
dc.contributor.authorTAKAMIYA, M
dc.contributor.authorBOURS, V
dc.contributor.authorSIEBENLIST, U
dc.contributor.authorDOBRZANSKI, P
dc.contributor.authorBRAVO, R
dc.date.accessioned2025-01-23T19:22:19Z
dc.date.available2025-01-23T19:22:19Z
dc.date.issued1992
dc.description.abstractWe have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional activation analysis of GAL4-RelB fusion proteins in yeast cells reveals that RelB contains in its C-terminal 180 amino acids a transcriptional activation domain. The N-terminal part including the region of similarity with the Rel family shows no detectable transcriptional activity. RelB does not bind with high affinity to NF-kappa-B sites, but heterodimers between RelB and p50-NF-kappa-B do bind to different NF-kappa-B-binding sites with a similar affinity to that shown by p50-NF-kappa-B homodimers. However, RelB/p50-NF-kappa-B heterodimers, in contrast to p50-NF-kappa-B homodimers, transactivate transcription of a promoter containing a kappa-B-binding site.
dc.fuente.origenWOS
dc.identifier.issn0270-7306
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99013
dc.identifier.wosidWOS:A1992HB06600023
dc.issue.numero2
dc.language.isoen
dc.pagina.final684
dc.pagina.inicio674
dc.revistaMolecular and cellular biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRELB, A NEW REL FAMILY TRANSCRIPTION ACTIVATOR THAT CAN INTERACT WITH P50-NF-KAPPA-B
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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