Simultaneous voltammetric determination of acetylsalicylic acid, caffeine and paracetamol in pharmaceutical formulations using screen-printed carbon electrode
No Thumbnail Available
Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Electrochemical oxidation of Paracetamol (PAR), Acetylsalicylic acid (ASA) and Caffeine (CAF) was investigated employing square wave stripping voltammetry (SWSV) using screen-printed carbon electrodes (SPCE). Determinations were performed in 0.1 mol L-1 BR buffer (pH 2.0) without accumulation step. SWV were obtained by scanning the potential from 0.00 to 1.40 V employing a scan increment of 4 mV, pulse amplitude 25 mV and frequency of 25 Hz. PAR, ASA and CAF presents oxidation signals at 0.45, 1.03 and 1.32 V. The detection limits were 1.2, 1.7 and 1.7 mg L-1, respectively. The method was applied in the PAR-ASA-CAF determination on pharmaceutical formulations.
Description
Keywords
acetylsalicylic acid, adsorptive stripping voltammetry, boron doped diamond electrode, caffeine, carbon screen printed electrode, paracetamol