Integrating the effects of sucrose intake on the brain and white adipose tissue: Could autophagy be a possible link?

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dc.catalogadorjwg
dc.contributor.authorMattar, Pamela
dc.contributor.authorToledo-Valenzuela, Lilian
dc.contributor.authorPaz Hernandez-Caceres, María
dc.contributor.authorPena-Oyarzun, Daniel
dc.contributor.authorMorselli, Eugenia
dc.contributor.authorPerez Leighton Claudio Esteban
dc.date.accessioned2024-11-14T14:44:48Z
dc.date.available2024-11-14T14:44:48Z
dc.date.issued2022
dc.description.abstractExcess dietary sucrose is associated with obesity and metabolic diseases. This relationship is driven by the malfunction of several cell types and tissues critical for the regulation of energy balance, including hypothalamic neurons and white adipose tissue (WAT). However, the mechanisms behind these effects of dietary sucrose are still unclear and might be independent of increased adiposity. Accumulating evidence has indicated that dysregulation of autophagy, a fundamental process for maintenance of cellular homeostasis, alters energy metabolism in hypothalamic neurons and WAT, but whether autophagy could mediate the detrimental effects of dietary sucrose on hypothalamic neurons and WAT that contribute to weight gain is a matter of debate. In this review, we examine the hypothesis that dysregulated autophagy in hypothalamic neurons and WAT is an adiposity-independent effect of sucrose that contributes to increased body weight gain. We propose that excess dietary sucrose leads to autophagy unbalance in hypothalamic neurons and WAT, which increases caloric intake and body weight, favoring the emergence of obesity and metabolic diseases.
dc.description.funderFONDECYT
dc.fuente.origenORCID
dc.identifier.doi10.1002/oby.23411
dc.identifier.eissn1930-739X
dc.identifier.issn1930-7381
dc.identifier.urihttps://doi.org/10.1002/oby.23411
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88550
dc.identifier.wosidWOS:000796377600001
dc.information.autorucFacultad de Ciencias Biológicas; Perez Leighton Claudio Esteban; 0000-0003-1817-6314; 126972
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final1155
dc.pagina.inicio1143
dc.publisherWILEY
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntegrating the effects of sucrose intake on the brain and white adipose tissue: Could autophagy be a possible link?
dc.typeartículo
dc.volumen30
sipa.codpersvinculados126972
sipa.trazabilidadORCID;2024-11-11
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