A decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility

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dc.contributor.authorBunay, Julio
dc.contributor.authorGallardo, Luz-Maria
dc.contributor.authorLuis Torres-Fuentes, Jorge
dc.contributor.authorVeronica Aguirre-Arias, M.
dc.contributor.authorOrellana, Renan
dc.contributor.authorSepulveda, Nestor
dc.contributor.authorMoreno, Ricardo D.
dc.date.accessioned2025-01-20T22:23:59Z
dc.date.available2025-01-20T22:23:59Z
dc.date.issued2021
dc.description.abstractObesity is a major worldwide health problem that is related to most chronic diseases, including male infertility. Owing to its wide impact on health, mechanisms underlying obesity-related infertility remain unknown. In this study, we report that mice fed a high-fat diet (HFD) for over 2 months showed reduced fertility rates and increased germ cell apoptosis, seminiferous tubule degeneration, and decreased intratesticular estradiol (E2) and E2-to-testosterone ratio. Interestingly, we also detected a decrease in testicular fatty acid levels, behenic acid (C22:0), and docosahexaenoic acid (DHA, 22:6n-3), which may be related to the production of dysfunctional spermatozoa. Overall, we did not detect any changes in the frequency of seminiferous tubule stages, sperm count, or rate of in vitro capacitation. However, there was an increase in spontaneous and progesterone-induced acrosomal exocytosis (acrosome reaction) in spermatozoa from HFD-fed mice. These data suggest that a decrease in E2 and fatty acid levels influences spermatogenesis and some steps of acrosome biogenesis that will have consequences for fertilization. Thus, our results add new evidence about the adverse effect of obesity in male reproduction and suggest that the acrosomal reaction can also be affected under this condition.
dc.fuente.origenWOS
dc.identifier.doi10.4103/aja.aja_76_20
dc.identifier.eissn1745-7262
dc.identifier.issn1008-682X
dc.identifier.urihttps://doi.org/10.4103/aja.aja_76_20
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94710
dc.identifier.wosidWOS:000647547100013
dc.issue.numero3
dc.language.isoen
dc.pagina.final313
dc.pagina.inicio306
dc.revistaAsian journal of andrology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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