Evaluation of myocarditis with a free-breathing three-dimensional isotropic whole-heart joint T1 and T2 mapping sequence

Simple item page
dc.article.number101100
dc.catalogadorvzp
dc.contributor.authorHua, Alina
dc.contributor.authorVelasco, Carlos
dc.contributor.authorMunoz, Camila
dc.contributor.authorMilotta, Giorgia
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorBosio, Filippo
dc.contributor.authorGranlund, Inka
dc.contributor.authorSularz, Agata
dc.contributor.authorChiribiri, Amedeo
dc.contributor.authorKunze, Karl P.
dc.contributor.authorBotnar Rene, Michael
dc.contributor.authorPrieto Vásquez, Claudia Del Carmen
dc.contributor.authorIsmail, Tevfik F.
dc.date.accessioned2025-03-07T12:01:05Z
dc.date.available2025-03-07T12:01:05Z
dc.date.issued2024
dc.description.abstractBackground: The diagnosis of myocarditis by cardiovascular magnetic resonance (CMR) requires the use of T2 and T1 weighted imaging, ideally incorporating parametric mapping. Current two-dimensional (2D) mapping sequences are acquired sequentially and involve multiple breath-holds resulting in prolonged scan times and anisotropic image resolution. We developed an isotropic free-breathing three-dimensional (3D) whole-heart sequence that allows simultaneous T1 and T2 mapping and validated it in patients with suspected myocarditis. Methods: Eighteen healthy volunteers and 28 patients with suspected myocarditis underwent conventional 2D T1 and T2 mapping with whole-heart coverage and 3D joint T1/T2 mapping on a 1.5T scanner. Acquisition time, image quality, and diagnostic performance were compared. Qualitative analysis was performed using a 4-point Likert scale. Bland-Altman plots were used to assess the quantitative agreement between 2D and 3D sequences. Results: The 3D T1/T2 sequence was acquired in 8 min 26 s under free breathing, whereas 2D T1 and T2 sequences were acquired with breath-holds in 11 min 44 s (p = 0.0001). All 2D images were diagnostic. For 3D images, 89% (25/ 28) of T1 and 96% (27/28) of T2 images were diagnostic with no significant difference in the proportion of diagnostic images for the 3D and 2D T1 (p = 0.2482) and T2 maps (p = 1.0000). Systematic bias in T1 was noted with biases of 102, 115, and 152 ms for basal-apical segments, with a larger bias for higher T1 values. Good agreement between T2 values for 3D and 2D techniques was found (bias of 1.8, 3.9, and 3.6 ms for basal-apical segments). The sensitivity and specificity of the 3D sequence for diagnosing acute myocarditis were 74% (95% confidence interval [CI] 49%-91%) and 83% (36%-100%), respectively, with a c-statistic (95% CI) of 0.85 (0.79-0.91) and no statistically significant difference between the 2D and 3D sequences for the detection of acute myocarditis for T1 (p = 0.2207) or T2 (p = 1.0000). Conclusion: Free-breathing whole-heart 3D joint T1/T2 mapping was comparable to 2D mapping sequences with respect to diagnostic performance, but with the added advantages of free breathing and shorter scan times. Further work is required to address the bias noted at high T1 values, but this did not significantly impact diagnostic accuracy.
dc.fechaingreso.objetodigital2025-03-07
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jocmr.2024.101100
dc.identifier.eissn1532-429X
dc.identifier.issn1097-6647
dc.identifier.urihttps://doi.org/10.1016/j.jocmr.2024.101100
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102418
dc.identifier.wosidWOS:001369386400001
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar Rene Michael; 0000-0003-2811-2509; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vasquez Claudia Del Carmen; 0000-0003-4602-2523; 14195
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherELSEVIER SCIENCE INC
dc.revistaJOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMyocarditis
dc.subjectMapping
dc.subjectMultiparametric
dc.subjectFree-breathing
dc.subjectWhole heart
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvaluation of myocarditis with a free-breathing three-dimensional isotropic whole-heart joint T1 and T2 mapping sequence
dc.typeartículo
dc.volumen26
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadWOS;2024-12-14
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Evaluation of myocarditis with a free-breathing three-dimensional isotropic whole-heart joint T1 and T2 mapping sequence.pdf
Size:
6.88 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas