Central Obesity and the Metabolic Syndrome Are Associated with Portal and Not Systemic Hypercortisolism Supported by the Raise of Urinary Corticosteroid Metabolites

Simple item page
dc.article.number106217
dc.contributor.authorBaudrand, R.
dc.contributor.authorCampino, C.
dc.contributor.authorCarvajal, C. A.
dc.contributor.authorOlivieri, O.
dc.contributor.authorGuidi, G.
dc.contributor.authorFaccini, G.
dc.contributor.authorPasini, F.
dc.contributor.authorSateler, J.
dc.contributor.authorCornejo, J.
dc.contributor.authorSan Martin, B.
dc.contributor.authorDominguez, J. M.
dc.contributor.authorMosso, L. M.
dc.contributor.authorOwen, G.
dc.contributor.authorKalergis, A. M.
dc.contributor.authorFardella, C.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:24Z
dc.date.available2024-08-15T08:00:24Z
dc.date.issued2010
dc.description.abstractBackground: There is paucity of information about bone metabolism during pregnancy or breast feeding in teenagers. Aim: To study bone turnover at the end of pregnancy and during breast feeding in teenagers and correlate it with environmental, hormonal or nutritional variables. Subjects and methods: Thirty teenagers during their breast feeding period after a first pregnancy and 30 nulliparous girls matched for age, age of menarche and body mass index were assessed three weeks after delivery (period 1), at six months of breast feeding (period 2) and one year after the lactating period (period 3). Calcium intake and plasma calcium, phosphorus, alkaline phosphatases, parathormone, estradiol and prolactin were measured. Calcium, creatinine and hydroxypyroline were also measured in a morning urine samples. Results: Lactating and control girls were aged 16.3+/-0.8 and 16.1+/-0.7 years old respectively. Calcium intake in lactating and control girls was 798+/-421 and 640+/-346 g/day respectively in period 1, 612+/-352 and 592+/-309 mg/day in period 2 and 495+/-180 and 456+/-157 g/day in period 3. During periods 1 and 2, lactating girls had higher alkaline phosphatases (161+/-37 compared to 119+/-28 U/l and 149+/-37 compared to 106+/-23 U/l), parathormone (4.3+/-2.6 compared to 2/8+/-0.8 ng/dl and 3.6+/-1.6 compared to 3.0+/-0.9 ng/dl) and urinary hydroxyproline (95+/-16 compared to 63+/-15 mg/g creatinine and 84+/-19 compared to 59+/-15 mg/g creatinine). No differences were observed in period 3. No correlation between bone turnover variables, body mass index or hormonal parameters, was observed. Conclusions: In teenagers, there is an increase in bone turnover at the end of pregnancy, that persists during the lactating period. These changes are not relaxed to nutritional or hormonal variables.
dc.description.funderANID through FONDECYT
dc.format.extent1 página
dc.fuente.origenWOS
dc.identifier.doi10.1161/01.HYP.34.4.779
dc.identifier.eissn1524-4563
dc.identifier.issn0163-769X
dc.identifier.pubmedidMEDLINE:10962882
dc.identifier.scopusidSCOPUS_ID:0346985951
dc.identifier.urihttps://doi.org/10.1161/01.HYP.34.4.779
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87470
dc.identifier.wosidWOS:000281989400083
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero3
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final153
dc.pagina.inicio145
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectbone demineralization, pathologic
dc.subjectlactation
dc.subjectosteoporosis
dc.subjectpregnancy in adolescence
dc.subjectPARATHYROID-HORMONE
dc.subjectMINERAL STATUS
dc.subjectCALCIUM REQUIREMENTS
dc.subjectBIOCHEMICAL MARKERS
dc.subjectADOLESCENT GIRLS
dc.subjectDIETARY CALCIUM
dc.subjectLUMBAR SPINE
dc.subjectWOMEN
dc.subjectDENSITY
dc.subjectMASS
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titleCentral Obesity and the Metabolic Syndrome Are Associated with Portal and Not Systemic Hypercortisolism Supported by the Raise of Urinary Corticosteroid Metabolites
dc.typecomunicación de congreso
dc.volumen31
sipa.codpersvinculados88201
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
Files
Collections
Artículos de conferencia