Surface enhanced fluorescence effect improves the <i>in vivo</i> detection of amyloid aggregates

Simple item page
dc.contributor.authorCabrera, Pablo
dc.contributor.authorJara-Guajardo, Pedro
dc.contributor.authorOyarzun, Maria Paz
dc.contributor.authorParra-Munoz, Nicole
dc.contributor.authorCampos, Aldo
dc.contributor.authorSoler, Monica
dc.contributor.authorAlvarez, Alejandra
dc.contributor.authorMorales-Zavala, Francisco
dc.contributor.authorAraya, Eyleen
dc.contributor.authorMinniti, Alicia N.
dc.contributor.authorAldunate, Rebeca
dc.contributor.authorKogan, Marcelo J.
dc.date.accessioned2025-01-20T21:04:03Z
dc.date.available2025-01-20T21:04:03Z
dc.date.issued2022
dc.description.abstractThe beta-amyloid (A beta) peptide is one of the key etiological agents in Alzheimer's disease (AD). The in vivo detection of A beta species is challenging in all stages of the illness. Currently, the development of fluorescent probes allows the detection of A beta in animal models in the near-infrared region (NIR). However, considering future applications in biomedicine, it is relevant to develop strategies to improve detection of amyloid aggregates using NIR probes. An innovative approach to increase the fluorescence signal of these fluorophores is the use of plasmonic gold nanoparticles (surface-enhanced fluorescence effect). In this work, we improved the detection of A beta aggregates in C. elegans and mouse models of AD by co-administering functionalized gold nanorods (GNRs-PEG-D1) with the fluorescent probes CRANAD-2 or CRANAD-58, which bind selectively to different amyloid species (soluble and insoluble). This work shows that GNRs improve the detection of A beta using NIR probes in vivo. (C) 2022 Published by Elsevier Inc.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.nano.2022.102569
dc.identifier.eissn1549-9642
dc.identifier.issn1549-9634
dc.identifier.urihttps://doi.org/10.1016/j.nano.2022.102569
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93207
dc.identifier.wosidWOS:000829546200002
dc.language.isoen
dc.revistaNanomedicine-nanotechnology biology and medicine
dc.rightsacceso restringido
dc.subjectbeta-Amyloid
dc.subjectGold nanorods
dc.subjectSurface enhanced fluorescence
dc.subjectCRANAD
dc.subjectC. elegans
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSurface enhanced fluorescence effect improves the <i>in vivo</i> detection of amyloid aggregates
dc.typeartículo
dc.volumen44
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas