Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence

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dc.contributor.authorAlves, Fernanda Cristina Bergamo
dc.contributor.authorde Oliveira, Rafael Guilen
dc.contributor.authorReyes, David Rafael Abreu
dc.contributor.authorGarcia, Gabriela Azevedo
dc.contributor.authorFloriano, Juliana Ferreira
dc.contributor.authorShetty, Raghavendra Hallur Lakshmana
dc.contributor.authorMareco, Edson Assuncao
dc.contributor.authorDal-Pai-Silva, Maeli
dc.contributor.authorPayao, Spencer Luiz Marques
dc.contributor.authorSouza, Fatima Pereira de
dc.contributor.authorWitkin, Steven S.
dc.contributor.authorSobrevia, Luis
dc.contributor.authorBarbosa, Angelica Mercia Pascon
dc.contributor.authorRudge, Marilza Vieira Cunha
dc.date.accessioned2025-01-20T21:01:25Z
dc.date.available2025-01-20T21:01:25Z
dc.date.issued2022
dc.description.abstractGestational diabetes mellitus (GDM) is recognized as a "window of opportunity" for the future prediction of such complications as type 2 diabetes mellitus and pelvic floor muscle disorders, including urinary incontinence and genitourinary dysfunction. Translational studies have reported that pelvic floor muscle disorders are due to a GDM-induced-myopathy (GDiM) of the pelvic floor muscle and rectus abdominis muscle (RAM). We now describe the transcriptome profiling of the RAM obtained by Cesarean section from GDM and non-GDM women with and without pregnancy-specific urinary incontinence (PSUI). We identified 650 genes in total, and the differentially expressed genes were defined by comparing three control groups to the GDM with PSUI group (GDiM). Enrichment analysis showed that GDM with PSUI was associated with decreased gene expression related to muscle structure and muscle protein synthesis, the reduced ability of muscle fibers to ameliorate muscle damage, and the altered the maintenance and generation of energy through glycogenesis. Potential genetic muscle biomarkers were validated by RT-PCR, and their relationship to the pathophysiology of the disease was verified. These findings help elucidate the molecular mechanisms of GDiM and will promote the development of innovative interventions to prevent and treat complications such as post-GDM urinary incontinence.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms232112864
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms232112864
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92881
dc.identifier.wosidWOS:000882106100001
dc.issue.numero21
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectgestational diabetes mellitus (GDM)
dc.subjectpregnancy-specific urinary incontinence (PSUI)
dc.subjectrectus abdominis muscle (RAM)
dc.subjecttranscriptomic profile
dc.subjectgestational diabetic-induced myopathy (GDiM)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTranscriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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