MUSCLE ENZYMATIC CHANGES INDUCED BY BLOCKAGE OF AXOPLASMIC-TRANSPORT

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dc.contributor.authorINESTROSA, NC
dc.contributor.authorFERNANDEZ, HL
dc.date.accessioned2025-01-23T19:45:01Z
dc.date.available2025-01-23T19:45:01Z
dc.date.issued1976
dc.description.abstractThe activity of malic dehydrogenase, pyruvic kinase and phosphorylase b was measured in the geniohyoid muscle of the cat after injection of 10 mM colchicine into the hypoglossal nerve. Experiments performed 1-60 days after the injection showed that the activity of the 3 enzymes gradually decreased (day 4-5), reached a maximum fall (day 10-25) and subsequently returned to control values (day 30-60). Concomitant to these enzymatic alterations, the muscles showed fibrillation and ACh [acetylcholine] hypersensitivity; however, in contrast to denervation, the drug had no effect on nerve conduction, effective neuromuscular transmission and the ultrastructure of motor end plates. Experiments with (3H) colchicine indicated that the observed changes were brought about by the drug acting directly on the motor axons rather than on the muscle cells. The transsynaptic effects induced by colchicine treatment to the nerve can be ascribed to a temporary interruption of axoplasmic transport. Neurotrophic regulation of some muscle-soluble enzymes may partly depend on the normal operation of the axoplasmic system.
dc.fuente.origenWOS
dc.identifier.eissn1522-1598
dc.identifier.issn0022-3077
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100185
dc.identifier.wosidWOS:A1976CP95200009
dc.issue.numero6
dc.language.isoen
dc.pagina.final1245
dc.pagina.inicio1236
dc.revistaJournal of neurophysiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMUSCLE ENZYMATIC CHANGES INDUCED BY BLOCKAGE OF AXOPLASMIC-TRANSPORT
dc.typeartículo
dc.volumen39
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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