Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research

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dc.contributor.authorSchepps, Samuel
dc.contributor.authorXu, Jonathan
dc.contributor.authorYang, Henry
dc.contributor.authorMandel, Jenna
dc.contributor.authorMehta, Jaanvi
dc.contributor.authorTolotta, Julianna
dc.contributor.authorBaker, Nicole
dc.contributor.authorTekmen, Volkan
dc.contributor.authorNikbakht, Neda
dc.contributor.authorFortina, Paolo
dc.contributor.authorFuentes, Ignacia
dc.contributor.authorLafleur, Bonnie
dc.contributor.authorCho, Raymond J.
dc.contributor.authorSouth, Andrew P.
dc.date.accessioned2025-01-20T17:05:31Z
dc.date.available2025-01-20T17:05:31Z
dc.date.issued2024
dc.description.abstractSingle-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.
dc.fuente.origenWOS
dc.identifier.doi10.1515/cclm-2023-1245
dc.identifier.eissn1437-4331
dc.identifier.issn1434-6621
dc.identifier.urihttps://doi.org/10.1515/cclm-2023-1245
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90728
dc.identifier.wosidWOS:001207438500001
dc.issue.numero10
dc.language.isoen
dc.pagina.final1891
dc.pagina.inicio1880
dc.revistaClinical chemistry and laboratory medicine
dc.rightsacceso restringido
dc.subjectspatial transcriptomics
dc.subjectgene expression
dc.subjectskin
dc.subjectsingle cell transcriptomics
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSkin in the game: a review of single-cell and spatial transcriptomics in dermatological research
dc.typeartículo
dc.volumen62
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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