The innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function

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dc.article.number1563401
dc.catalogadorgjm
dc.contributor.authorFuenzalida Uribe, Nicolás Leonardo
dc.contributor.authorHidalgo Sotelo, Sergio Ignacio
dc.contributor.authorSilva Bustos, Bryon Arnaldo
dc.contributor.authorGandhi, Saurin
dc.contributor.authorVo, David
dc.contributor.authorZamani, Parham
dc.contributor.authorHolmes, Todd C.
dc.contributor.authorSayin, Sercan
dc.contributor.authorGrunwald Kadow, Ilona C.
dc.contributor.authorHadjieconomou, Dafni
dc.contributor.authorO'Dowd, Diane K.
dc.contributor.authorCampusano Astorga, Jorge Mauricio
dc.date.accessioned2025-05-22T14:44:46Z
dc.date.available2025-05-22T14:44:46Z
dc.date.issued2025
dc.description.abstractIn the mammalian olfactory bulb (OB), gap junctions coordinate synchronous activity among mitral and tufted cells to process olfactory information. In insects, gap junctions are also present in the antennal lobe (AL), a structure homologous to the mammalian OB. The invertebrate gap junction protein ShakB contributes to electrical synapses between AL projection neurons (PNs) in Drosophila. Other gap junction proteins, including innexin 7 (Inx7), are also expressed in the Drosophila AL, but little is known about their contribution to intercellular communication during olfactory information processing. In this study, we report spontaneous calcium transients in PNs grown in cell culture that are highly synchronous when these neurons are physically connected. RNAi-mediated knockdown of Inx7 in cultured PNs blocks calcium transient neuronal synchronization. In vivo, downregulation of Inx7 in the AL impairs both vinegar-induced electrophysiological calcium responses and behavioral responses to this appetitive stimulus. These results demonstrate that Inx7-encoded gap junctions functionally coordinate PN activity and modulate olfactory information processing in the adult Drosophila AL.
dc.description.funderNRW
dc.description.funderFONDECYT
dc.description.funderERC
dc.description.funderGerman Research Foundation
dc.description.funderNIH
dc.fechaingreso.objetodigital2025-05-22
dc.format.extent10 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.3389/fncir.2025.1563401
dc.identifier.issn1662-5110
dc.identifier.scopusidSCOPUS_ID:105004450454
dc.identifier.urihttps://doi.org/10.3389/fncir.2025.1563401
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104431
dc.information.autorucFacultad de Ciencias Biológicas; Fuenzalida Uribe, Nicolás Leonardo; S/I; 149110
dc.information.autorucFacultad de Ciencias Biológicas; Hidalgo Sotelo, Sergio Ignacio; 0000-0002-2604-156X; 205482
dc.information.autorucFacultad de Ciencias Biológicas; Silva Bustos, Bryon Arnaldo; S/I; 186017
dc.information.autorucFacultad de Ciencias Biológicas; Campusano Astorga, Jorge Mauricio; 0000-0001-5254-8340; 3965
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaFrontiers in Neural Circuits
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCalcium dynamics
dc.subjectDrosophila
dc.subjectGap junction
dc.subjectInnexin
dc.subjectOlfactory information
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function
dc.typeartículo
dc.volumen19
sipa.codpersvinculados149110
sipa.codpersvinculados205482
sipa.codpersvinculados186017
sipa.codpersvinculados3965
sipa.trazabilidadSCOPUS;2025-05-18
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