"Do depressive and manic symptoms differentially impact on functioning in acute depression? Results from a large, cross-sectional study"

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dc.contributor.authorAnmella, Gerard
dc.contributor.authorGil-Badenes, Joaquin
dc.contributor.authorPacchiarotti, Isabella
dc.contributor.authorVerdolini, Norma
dc.contributor.authorAedo, Alberto
dc.contributor.authorAngst, Jules
dc.contributor.authorAzorin, Jean-Michel
dc.contributor.authorBowden, Charles L.
dc.contributor.authorMosolov, Sergey
dc.contributor.authorSamalin, Ludovic
dc.contributor.authorPopovic, Dina
dc.contributor.authorYoung, Allan H.
dc.contributor.authorPerugi, Giulio
dc.contributor.authorVieta, Eduard
dc.contributor.authorMurru, Andrea
dc.date.accessioned2025-01-23T19:57:14Z
dc.date.available2025-01-23T19:57:14Z
dc.date.issued2020
dc.description.abstractBackground: Diagnostic criteria for a major depressive episode capture heterogeneous presentations across unipolar (UD) and bipolar (BD) and first-onset (FDE) depression. We evaluated the contribution of each depressive and (hypo)manic symptom to worse functioning in UD/BD/FDE subgroups.
dc.description.abstractMethods: A post-hoc analysis of the BRIDGE-II-Mix study. Acutely depressed patients were stratified into UD, BD and FDE. Each (hypo)manic or depressive symptom was included in a diagnosis-specific logistic regression model with functioning as dependent variable. Better/worse functioning was set with median diagnosis-specific GAF scores cutoffs. All p values were two-tailed. Statistical significance was set at p < 0.05.
dc.description.abstractResults: A total of 2768/2811 depressed individuals were enrolled. In BD (N= 716), "recurrent thoughts of death" (OR 2.48, p < 0.0001) and "feelings of worthlessness" (OR 2.28, p < 0.0001) among depressive symptoms, "aggressiveness" (OR 1.67, p= 0.022) as the unique (hypo)manic symptom, significantly contributed to worse functioning. In UD (N= 1357), "depressed mood" (OR 5.6, p= 0.031) and "diminished interest or pleasure" (OR 4.77, p < 0.0001) among depressive, "grandiosity" (OR 3.5, p= 0.014) among (hypo)manic symptoms, most significantly contributed to worse functioning. In FDE (N= 677) "recurrent thoughts of death" (OR 1.99, p < 0.0001) and "insomnia/hypersomnia" (OR 1.88, p= 0.039) among depressive, "grandiosity" (OR 5.98, p= 0.038) as (hypo)manic symptoms significantly contributed to worse functioning.
dc.description.abstractLimitations: The post-hoc and cross-sectional design do not allow for prognostic or causal inferences.
dc.description.abstractConclusions: Key depressive and (hypo)manic symptoms distinctively associate with worse functional outcome in acute depression, with differential diagnostic-specific magnitude of effect. Core depressive symptoms are associated with worse functioning in unipolar depression, but not in bipolar or first-episode depression.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jad.2019.09.070
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.urihttps://doi.org/10.1016/j.jad.2019.09.070
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100731
dc.identifier.wosidWOS:000499616400004
dc.language.isoen
dc.pagina.final39
dc.pagina.inicio30
dc.revistaJournal of affective disorders
dc.rightsacceso restringido
dc.subjectSymptoms
dc.subjectFunctioning
dc.subjectMajor depressive episode
dc.subjectBipolar depression
dc.subjectBRIDGE-II-Mix
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title"Do depressive and manic symptoms differentially impact on functioning in acute depression? Results from a large, cross-sectional study"
dc.typeartículo
dc.volumen261
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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