PALMITOYL-COA AND THE ACYL-COA THIOESTER OF THE CARCINOGENIC PEROXISOME-PROLIFERATOR CIPROFIBRATE POTENTIATE DIACYLGLYCEROL-ACTIVATED PROTEIN KINASE-C BY DECREASING THE PHOSPHATIDYLSERINE REQUIREMENT OF THE ENZYME

Simple item page
dc.contributor.authorORELLANA, A
dc.contributor.authorHIDALGO, PC
dc.contributor.authorMORALES, MN
dc.contributor.authorMEZZANO, D
dc.contributor.authorBRONFMAN, M
dc.date.accessioned2025-01-23T19:23:13Z
dc.date.available2025-01-23T19:23:13Z
dc.date.issued1990
dc.description.abstractTo gain insight into the mechanism by which long-chain acyl-CoA thioesters potentiate diacylglycerol-activated protein kinase C, the cofactor dependence of this activating effect was studied with purified rat brain enzyme and histone H1 as substrate. Using two different assay systems, palmitoyl-CoA was found to decrease greatly the amount of phosphatidylserine required to activate the kinase. No relative changes were observed in the dependence of the enzyme for other cofactors (diacylglycerol, ATP, and Ca2+) in the presence of palmitoyl-CoA. The potentiating effect of palmitoyl-CoA and the decrease in phosphatidylserine requirement of the kinase was also demonstrated using the 47-kDa protein of human platelets as substrate and platelet protein kinase C as source of enzyme. The acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate was also found to decrease the phosphatidylserine requirement of protein kinase C. The data suggest that acyl-CoAs may play a role in the regulation of protein kinase C activity.
dc.fuente.origenWOS
dc.identifier.issn0014-2956
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99178
dc.identifier.wosidWOS:A1990DK80500008
dc.issue.numero1
dc.language.isoen
dc.pagina.final61
dc.pagina.inicio57
dc.revistaEuropean journal of biochemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePALMITOYL-COA AND THE ACYL-COA THIOESTER OF THE CARCINOGENIC PEROXISOME-PROLIFERATOR CIPROFIBRATE POTENTIATE DIACYLGLYCEROL-ACTIVATED PROTEIN KINASE-C BY DECREASING THE PHOSPHATIDYLSERINE REQUIREMENT OF THE ENZYME
dc.typeartículo
dc.volumen190
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas