Risk Stratification and Validation of Prostate Specific Antigen Density as Independent Predictor of Progression in Men With Low Risk Prostate Cancer During Active Surveillance

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dc.contributor.authorFrancisco, Ignacio F. San
dc.contributor.authorWerner, Lillian
dc.contributor.authorRegan, Meredith M.
dc.contributor.authorGarnick, Marc B.
dc.contributor.authorBubley, Glenn
dc.contributor.authorDeWolf, William C.
dc.date.accessioned2024-01-10T13:17:20Z
dc.date.available2024-01-10T13:17:20Z
dc.date.issued2011
dc.description.abstractPurpose: We assessed risk stratification in patients with low grade prostate cancer managed by active surveillance using a 20-core saturation biopsy technique.
dc.description.abstractMaterials and Methods: A total of 135 consecutive patients with low risk prostate cancer were prospectively entered in an active surveillance program in a 10-year period. The study entrance requirement and progression definition followed Epstein criteria using only pathological parameters, ie fewer than 3 positive cores, Gleason score 6 or less and 50% or less of any single core involved. All patients were monitored by restaging 20-core saturation biopsy every 12 to 18 months. A total of 120 patients with at least 1 rebiopsy form the basis of this report.
dc.description.abstractResults: Of the cohort 30% progressed during a median of 2.4 years. Three multivariate analyses were performed. The first analysis used variables only at diagnosis biopsy and revealed that prostate specific antigen density greater than 0.08 ng/ml/cc and prostate cancer family history were significant predictors of progression. When combined in a 3-level risk factor score, they were significant (p = 0.003). The second multivariate analysis considered changes in characteristics between diagnosis biopsy and first rebiopsy. Prostate specific antigen velocity along with prostate specific antigen density and family history highly predicted progression according to a 4-level risk factor score (p < 0.0001). The third multivariate analysis validated the previously reported prostate specific antigen density cutoff of 0.08 ng/ml/cc at first rebiopsy as a significant predictor of subsequent progression (HR 3.16, 95% CI 1.12, 8.93; p = 0.03).
dc.description.abstractConclusions: Risk factor stratification can be used to significantly predict the outcome in patients on active surveillance. Prostate specific antigen density 0.08 ng/ml/cc at first rebiopsy was validated as a significant predictor of subsequent progression.
dc.description.funderHershey Family Fund
dc.fechaingreso.objetodigital01-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.juro.2010.09.115
dc.identifier.eissn1527-3792
dc.identifier.issn0022-5347
dc.identifier.pubmedidMEDLINE:21167525
dc.identifier.urihttps://doi.org/10.1016/j.juro.2010.09.115
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78655
dc.identifier.wosidWOS:000286047500032
dc.information.autorucMedicina;San Francisco I ;S/I;152729
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final476
dc.pagina.inicio471
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF UROLOGY
dc.rightsacceso restringido
dc.subjectprostate
dc.subjectprostatic neoplasms
dc.subjectprostate-specific antigen
dc.subjectbiopsy
dc.subjectrisk
dc.subjectEXPECTANT MANAGEMENT
dc.subjectCURATIVE INTENT
dc.subjectBIOPSY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk Stratification and Validation of Prostate Specific Antigen Density as Independent Predictor of Progression in Men With Low Risk Prostate Cancer During Active Surveillance
dc.typeartículo
dc.volumen185
sipa.codpersvinculados152729
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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