Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-beta-peptides

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dc.contributor.authorAlvarez, A
dc.contributor.authorBronfman, F
dc.contributor.authorPerez, CA
dc.contributor.authorVicente, M
dc.contributor.authorGarrido, J
dc.contributor.authorInestrosa, NC
dc.date.accessioned2025-01-21T01:34:22Z
dc.date.available2025-01-21T01:34:22Z
dc.date.issued1995
dc.description.abstractAcetylcholinesterase (AChE) colocalizes with amyloid-beta peptide (A beta) deposits present in the brain of Alzheimer's patients. Recent studies showed that A beta(1-40) Can adopt two different conformational states in solution (an amyloidogenic conformer, A beta ac, and a non-amyloidogenic conformer, A beta nac) which have distinct abilities to form amyloid fibrils. We report here that AChE binds A beta nac and accelerates amyloid formation by the same peptide. No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a 'pathological chaperone' inducing a conformational transition from A beta nac into A beta ac in vitro.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97549
dc.identifier.wosidWOS:A1995TK80800013
dc.issue.numero1
dc.language.isoen
dc.pagina.final52
dc.pagina.inicio49
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectacetylcholinesterase
dc.subjectbrain G(4)
dc.subjectsynthetic amyloid-beta peptides
dc.subjectfibrillogenesis
dc.subjectAlzheimer's disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAcetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-beta-peptides
dc.typeartículo
dc.volumen201
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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