Antiribosomal P protein antibodies in Chilean SLE patients

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dc.contributor.authorMassardo, L
dc.contributor.authorBurgos, P
dc.contributor.authorMartínez, ME
dc.contributor.authorPérez, R
dc.contributor.authorCalvo, M
dc.contributor.authorBarros, M
dc.contributor.authorGonzález, A
dc.contributor.authorJacobelli, S
dc.date.accessioned2025-01-21T01:30:36Z
dc.date.available2025-01-21T01:30:36Z
dc.date.issued2002
dc.description.abstractThe objective of this work was to determine the frequency and clinical associations of antiribosomal P protein antibodies (Anti-P) in a cohort of Chilean patients with systemic lupus erythematosus (SLE). Between 1996 and 1998, 141 consecutive patients with SLE,here examined prospectively according with a standard protocol. Disease activity was measured by MEX-SLEDAI in 138 patients. Anti-P positivity was determined by double immune diffusion or Western blot and ELISA. Anti-P was found in 21 (15%) patients, In the Anti-P positive patients recent onset SLE (disease duration of 1 year or less) was more frequent (P = 0.018). Anti-P was found in 73% of 83 patients with active SLE vs 4% of the 55 patients with inactive SLE (Yates corrected P = 0.00479). An association with anti-dsDNA antibodies by Farr assay was observed. Anti-P positive patients had a median Farr of 65IU/ml (1.4-1240) and Anti-P negative of 12IU/ml (1.4-992 P-value = 0.0084). During the study only two patients had lupus psychosis and they were Anti-P positive. No association,vas found with liver disease (six patients, two with Anti-P antibodies) or active glomerulonephritis (22 patients, four with Anti-P). Our data shows that the presence of Anti-P antibodies supports the clinical diagnosis of lupus psychosis.
dc.fuente.origenWOS
dc.identifier.doi10.1191/0961203302lu209oa
dc.identifier.issn0961-2033
dc.identifier.urihttps://doi.org/10.1191/0961203302lu209oa
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96823
dc.identifier.wosidWOS:000176791900007
dc.issue.numero6
dc.language.isoen
dc.pagina.final383
dc.pagina.inicio379
dc.revistaLupus
dc.rightsacceso restringido
dc.subjectantiribosomal P antibodies
dc.subjectlupus
dc.subjectclinical associations
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAntiribosomal P protein antibodies in Chilean SLE patients
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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