ACETYLCHOLINESTERASE AGGREGATES IN A NEWLY FORMED MOTOR-NERVE SMOOTH-MUSCLE JUNCTION

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dc.contributor.authorMENDEZ, B
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-23T19:44:20Z
dc.date.available2025-01-23T19:44:20Z
dc.date.issued1981
dc.description.abstractThe changes in acetylcholinesterase (AChE) molecular forms were studied during cross-innervation of the inferior smooth muscle of the cat nictitating membrane by the hypoglossal nerve. One month after functional cross-innervation AChE activity increased by 2-fold above control values, and a new high MW AChE form (A12) was detected. BW284c51 [1,5-bis-(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide], an anti-AChE, potentiated the contraction of the cross-innervated smooth muscle. AChE activity raised 6-fold above normal values 3 mo. later. At this time, half of the activity sediments to the bottom of the sucrose gradient and a time-dependent dissociation occurs in lighter AChE forms, reminiscent of AChE aggregates observed in the electric eel [Electrophorus electricus]. The multimolecular aggregates may be involved in the immobilization of AChE at the neuromuscular junction of a motor nerve and a smooth muscle.
dc.fuente.origenWOS
dc.identifier.eissn1873-2747
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100010
dc.identifier.wosidWOS:A1981MB62000004
dc.issue.numero1
dc.language.isoen
dc.pagina.final24
dc.pagina.inicio17
dc.revistaBrain research bulletin
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleACETYLCHOLINESTERASE AGGREGATES IN A NEWLY FORMED MOTOR-NERVE SMOOTH-MUSCLE JUNCTION
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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