Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study

Simple item page
dc.catalogadordfo
dc.contributor.authorPérez Jeldres, Tamara De Lourdes
dc.contributor.authorBustamante, M. Leonor
dc.contributor.authorSegovia-Melero, Roberto
dc.contributor.authorAguilar, Nataly
dc.contributor.authorMagne, Fabien
dc.contributor.authorAscui, Gabriel
dc.contributor.authorUribe, Denisse
dc.contributor.authorAzocar, Lorena
dc.contributor.authorHernández Rocha, Cristián Antonio
dc.contributor.authorEstela, Ricardo
dc.contributor.authorSilva, Veronica
dc.contributor.authorDe La Vega, Andres
dc.contributor.authorArriagada, Elizabeth
dc.contributor.authorGonzalez, Mauricio
dc.contributor.authorOnetto, Gian-Franco
dc.contributor.authorEscobar, Sergio
dc.contributor.authorBaez, Pablo
dc.contributor.authorZazueta, Alejandra
dc.contributor.authorPávez Ovalle Carolina Denisse
dc.contributor.authorMiquel Poblete, Juan Francisco
dc.contributor.authorÁlvarez Lobos Manuel Marcelo
dc.date.accessioned2024-08-09T16:23:03Z
dc.date.available2024-08-09T16:23:03Z
dc.date.issued2023
dc.description.abstractLactose intolerance (LI) and vitamin D deficiency (VDD) have been linked to inflammatory bowel disease (IBD). We conducted an observational study in 192 Chilean IBD patients to investigate the prevalence of a specific gene variant (LCT-13910 CC genotype) associated with LI and the prevalence of VDD/Vitamin D Receptor (VDR) gene variants. Blood samples were analyzed using Illumina's Infinium Global Screening Array. The LCT-13910 CC genotype was found in 61% of IBD patients, similar to Chilean Hispanic controls and lower than Chilean Amerindian controls. The frequency of the LCT-13910-C allele in Chilean IBD patients (0.79) was comparable to the general population and higher than Europeans (0.49). Regarding VDR and VDD variants, in our study, the rs12785878-GG variant was associated with an increased risk of IBD (OR = 2.64, CI = 1.61-4.32; p-value = 0.001). Sixty-one percent of the Chilean IBD cohort have a genetic predisposition to lactose malabsorption, and a significant proportion exhibit genetic variants associated with VDD/VDR. Screening for LI and VDD is crucial in this Latin American IBD population.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms241914866
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms241914866
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87394
dc.identifier.wosidWOS:001084376100001
dc.information.autorucEscuela de Medicina; Perez Jeldres Tamara De Lourdes; S/I; 1024946
dc.information.autorucEscuela de Medicina; Hernandez Rocha Cristian Antonio; 0000-0001-9018-4242; 175117
dc.information.autorucEscuela de Medicina; Pavez Ovalle Carolina Denisse; S/I; 190170
dc.information.autorucEscuela de Medicina; Miquel Poblete Juan Francisco; 0000-0002-0526-4377; 72216
dc.information.autorucEscuela de Medicina; Alvarez Lobos Manuel Marcelo; S/I; 6131
dc.issue.numero19
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.publisherMDPI
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectSingle-nucleotide polymorphism
dc.subjectLatin American
dc.subjectInflammatory bowel disease
dc.subjectVitamin D
dc.subjectLactose intolerance
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study
dc.typeartículo
dc.volumen24
sipa.codpersvinculados1024946
sipa.codpersvinculados175117
sipa.codpersvinculados190170
sipa.codpersvinculados72216
sipa.codpersvinculados6131
sipa.trazabilidadWOS;2023-11-04
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort; Insights from an Observational Study.pdf
Size:
479.72 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas