N-CHLOROACETYL 5-METHOXYTRYPTAMINE (ISAMIDE) - SELECTIVE ANTAGONIST OF 5-HYDROXYTRYPTAMINE IN THE RAT UTERUS

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dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorHUIDOBRO, F
dc.contributor.authorRUIZ, M
dc.date.accessioned2025-01-23T19:44:40Z
dc.date.available2025-01-23T19:44:40Z
dc.date.issued1979
dc.description.abstractIsamide, the N-chloracetyl derivative of 5-methoxytryptamine, produced a dose-dependent competitive blockade of uterine contractions in vitro induced by 5-HT [hydroxytryptamine]. The pA2 value for the 5-HT-isamide interaction was 4.42. The blockade was short-lasting and reversible; after recovery, a dose-dependent increase in the uterine sensitivity to 5-HT was found. The blockade was selective to the 5-HT receptor. The simultaneous application of 5-HT plus isamide partially prevented the 5-HT-induced auto blockade phenomenon. In addition, isamide did not affect the contractile responses of the uterus to oxytocin or bradykinin or the contractile effects of the rat vas deferens to adrenaline.
dc.fuente.origenWOS
dc.identifier.eissn2042-7158
dc.identifier.issn0022-3573
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100093
dc.identifier.wosidWOS:A1979GZ07700003
dc.issue.numero6
dc.language.isoen
dc.pagina.final374
dc.pagina.inicio371
dc.revistaJournal of pharmacy and pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleN-CHLOROACETYL 5-METHOXYTRYPTAMINE (ISAMIDE) - SELECTIVE ANTAGONIST OF 5-HYDROXYTRYPTAMINE IN THE RAT UTERUS
dc.typeartículo
dc.volumen31
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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