Oxygenation by Intravascular Photosynthesis Reduces Kidney Damage During ex Vivo Preservation

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dc.contributor.authorVeloso-Gimenez, Valentina
dc.contributor.authorCardenas-Calderon, Camila
dc.contributor.authorCastillo, Valentina
dc.contributor.authorCarvajal, Felipe
dc.contributor.authorGallardo-Aguero, Daniela
dc.contributor.authorGonzalez-Itier, Sergio
dc.contributor.authorCorrales-Orovio, Rocio
dc.contributor.authorBecerra, Daniela
dc.contributor.authorMiranda, Miguel
dc.contributor.authorRebolledo, Rolando
dc.contributor.authorSan Martin, Sebastian
dc.contributor.authorBoric, Mauricio P.
dc.contributor.authorEgana, Jose Tomas
dc.date.accessioned2025-01-20T16:04:35Z
dc.date.available2025-01-20T16:04:35Z
dc.date.issued2024
dc.description.abstractSeveral clinical issues are associated with reduced oxygen delivery to tissues due to impaired vascular perfusion; moreover, organs procured for transplantation are subjected to severe hypoxia during preservation. Consequently, alternative tissue oxygenation is an active field in biomedical research where several innovative approaches have been recently proposed. Among these, intravascular photosynthesis represents a promising approach as it relies on the intrinsic capacity of certain microorganisms to produce oxygen upon illumination. In this context, this work aims at the development of photosynthetic perfusable solutions that could be applied to preserve organs for transplantation purposes. Our findings demonstrate that a biocompatible physiological solution containing the photosynthetic microalgae Chlamydomonas reinhardtii can fulfill the metabolic oxygen demand of rat kidney slices in vitro. Furthermore, intravascular administration of this solution does not induce tissue damage in the rat kidneys. Moreover, kidney slices obtained from these algae-perfused organs exhibited significantly improved preservation after 24 h of incubation in hypoxia while exposed to light, resulting in reduced tissue damage and enhanced metabolic status. Overall, the results presented here contribute to the development of alternative strategies for tissue oxygenation, supporting the use of perfusable photosynthetic solutions for organ preservation in transplantation.
dc.fuente.origenWOS
dc.identifier.doi10.1021/acsabm.4c01327
dc.identifier.issn2576-6422
dc.identifier.urihttps://doi.org/10.1021/acsabm.4c01327
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89812
dc.identifier.wosidWOS:001351690200001
dc.language.isoen
dc.revistaAcs applied bio materials
dc.rightsacceso restringido
dc.subjectintravascular photosynthesis
dc.subjectChlamydomonas reinhardtii
dc.subjectorgan transplantation
dc.subjectoxygen delivery
dc.subjectphotosynthetictherapies
dc.titleOxygenation by Intravascular Photosynthesis Reduces Kidney Damage During ex Vivo Preservation
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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