Contemporary clinical profile and outcome of prosthetic valve endocarditis

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dc.contributor.authorWang, Andrew
dc.contributor.authorAthan, Eugene
dc.contributor.authorPappas, Paul A.
dc.contributor.authorFowler, Vance G., Jr.
dc.contributor.authorOlaison, Lars
dc.contributor.authorPare, Carlos
dc.contributor.authorAlmirante, Benito
dc.contributor.authorMunoz, Patricia
dc.contributor.authorRizzi, Marco
dc.contributor.authorNaber, Christoph
dc.contributor.authorLogar, Mateja
dc.contributor.authorTattevin, Pierre
dc.contributor.authorIarussi, Diana L.
dc.contributor.authorSelton Suty, Christine
dc.contributor.authorJones, Sandra Braun
dc.contributor.authorCasabe, Jose
dc.contributor.authorMorris, Arthur
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorCabell, Christopher H.
dc.contributor.otherInt Collaboration Endocarditis Pro
dc.date.accessioned2024-01-10T13:47:10Z
dc.date.available2024-01-10T13:47:10Z
dc.date.issued2007
dc.description.abstractContext Prosthetic valve endocarditis (PVE) is associated with significant mortality and morbidity. The contemporary clinical profile and outcome of PVE are not well defined. Objectives To describe the prevalence, clinical characteristics, and outcome of PVE, with attention to health care-associated infection, and to determine prognostic factors associated with in-hospital mortality. Design, Setting, and Participants Prospective, observational cohort study conducted at 61 medical centers in 28 countries, including 556 patients with definite PVE as defined by Duke University diagnostic criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to August 2005. Main Outcome Measure In-hospital mortality. Results Definite PVE was present in 556 (20.1%) of 2670 patients with infective endocarditis. Staphylococcus aureus was the most common causative organism (128 patients [23.0%]), followed by coagulase-negative staphylococci (94 patients [16.9%]). Health care-associated PVE was present in 203 (36.5%) of the overall cohort. Seventy-one percent of health care-associated PVE occurred within the first year of valve implantation, and the majority of cases were diagnosed after the early (60-day) period. Surgery was performed in 272 (48.9%) patients during the index hospitalization. In-hospital death occurred in 127 (22.8%) patients and was predicted by older age, health care associated infection (62/203 [30.5%]; adjusted odds ratio [OR], 1.62; 95% confidence interval [CI], 1.08-2.44; P = .02), S aureus infection (44/128 [34.4%]; adjusted OR, 1.73; 95% CI, 1.01-2.95; P = .05), and complications of PVE, including heart failure (60/183 [32.8%]; adjusted OR, 2.33; 95% CI, 1.62-3.34; P < .001), stroke (34/101 [33.7%]; adjusted OR, 2.25; 95% CI, 1.25-4.03; P = .007), intracardiac abscess (47/144 [32.6%]; adjusted OR, 1.86; 95% CI, 1.10-3.15; P = .02), and persistent bacteremia (27/49 [55.1%]; adjusted OR, 4.29; 95% CI, 1.99-9.22; P < .001). Conclusions Prosthetic valve endocarditis accounts for a high percentage of all cases of infective endocarditis in many regions of the world. Staphylococcus aureus is now the leading cause of PVE. Health care - associated infection significantly influences the clinical characteristics and outcome of PVE. Complications of PVE strongly predict in-hospital mortality, which remains high despite prompt diagnosis and the frequent use of surgical intervention.
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1001/jama.297.12.1354
dc.identifier.issn0098-7484
dc.identifier.pubmedidMEDLINE:17392239
dc.identifier.urihttps://doi.org/10.1001/jama.297.12.1354
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79242
dc.identifier.wosidWOS:000245212600022
dc.information.autorucMedicina;Jones S;S/I;99111
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1361
dc.pagina.inicio1354
dc.publisherAMER MEDICAL ASSOC
dc.revistaJAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
dc.rightsacceso restringido
dc.subjectINFECTIVE ENDOCARDITIS
dc.subjectMEDICAL PROGRESS
dc.subjectACQUIRED INFECTIONS
dc.subjectPROPENSITY ANALYSIS
dc.subjectDUKE CRITERIA
dc.subjectRISK-FACTORS
dc.subjectFOLLOW-UP
dc.subjectMORTALITY
dc.subjectDIAGNOSIS
dc.subjectADULTS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleContemporary clinical profile and outcome of prosthetic valve endocarditis
dc.typeartículo
dc.volumen297
sipa.codpersvinculados99111
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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