Renal function and cardiopulmonary bypass in pediatric cardiac surgical patients

Simple item page
dc.contributor.authorLema, Guillermo
dc.contributor.authorVogel, Andrea
dc.contributor.authorCanessa, Roberto
dc.contributor.authorJalil, Roberto
dc.contributor.authorCarvajal, Claudia
dc.contributor.authorBecker, Pedro
dc.contributor.authorJaque, Maria Paz
dc.contributor.authorFajardo, Christian
dc.contributor.authorUrzua, Jorge
dc.date.accessioned2025-01-21T01:05:53Z
dc.date.available2025-01-21T01:05:53Z
dc.date.issued2006
dc.description.abstractWe studied prospectively the perioperative changes of renal function in nine children undergoing cardiac surgery with cardiopulmonary bypass (CPB). Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured with inulin and I-131-hippuran clearances before CPB, during hypo and normothermic CPB, following sternal closure and 1 h postoperatively. Urinary alpha glutathione S-transferase (alpha GS-T) was measured pre- and postoperatively as a marker for tubular cellular damage. Plasma and urine creatinine and electrolytes were measured. Free water, osmolal and creatinine clearances, as well as fractional excretion of sodium (FeNa) and potassium transtubular gradient (TTKG) were calculated. GFR was normal before and after surgery. ERPF was low before and after surgery; it increased significantly immediately after CPB. Filtration fraction (FF) was abnormally elevated before and after surgery; however, a significant decrease during normothermic CPB and sternal closure was found. Alpha GS-T presented a moderate, but nonsignificant increase postoperatively. FeNa also increased in this period, but not significantly. Creatinine, osmolal, free water clearances, as well as TTKG, were normal in all patients pre- and postoperatively. We conclude that there is no evidence of clinically significant deterioration of renal function in children undergoing repair of cardiac lesions under CPB. Minor increases of alpha GS-T in urine postoperatively did not confirm cellular tubular damage. There was no tubular dysfunction at that time.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00467-006-0221-4
dc.identifier.issn0931-041X
dc.identifier.urihttps://doi.org/10.1007/s00467-006-0221-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96041
dc.identifier.wosidWOS:000240061500016
dc.issue.numero10
dc.language.isoen
dc.pagina.final1451
dc.pagina.inicio1446
dc.revistaPediatric nephrology
dc.rightsacceso restringido
dc.subjectcardiovascular anesthesia
dc.subjectcardiopulmonary bypass
dc.subjectrenal function
dc.subjectcardiac surgery
dc.subjectpediatrics
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRenal function and cardiopulmonary bypass in pediatric cardiac surgical patients
dc.typeartículo
dc.volumen21
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas