(-)-Epicatechin Solubility in Aqueous Mixtures of Eutectic Solvents and Their Constituents

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dc.contributor.authorBastias-Barra, Arturo I.
dc.contributor.authorGajardo-Parra, Nicolas F.
dc.contributor.authorCea-Klapp, Esteban
dc.contributor.authorArroyo-Avirama, Andres F.
dc.contributor.authorGarrido, Jose Matias
dc.contributor.authorHeld, Christoph
dc.contributor.authorPerez-Correa, Jose R.
dc.contributor.authorCanales, Roberto I.
dc.date.accessioned2025-01-20T16:04:41Z
dc.date.available2025-01-20T16:04:41Z
dc.date.issued2024
dc.description.abstract(-)-Epicatechin is a polyphenol present in diverse natural sources. It shows positive human health effects, which makes it interesting for the pharmaceutical and food industries. Conventional solvents used for polyphenol extraction are mostly toxic and flammable, leaving unwanted impurities in the final product. Thus, solubility of (-)-epicatechin at 101.3 kPa and 293.15, 303.15, and 313.15 K was experimentally measured in water and binary systems composed of 25 wt % of water + 1,3-propanediol (13PD), glycerol (Gly), and two deep eutectic solvents based on choline chloride as hydrogen-bond acceptor and the previous polyols as hydrogen-bond donors (DES1 and DES2). Solubility results in water were obtained using spectrophotometric and gravimetric methodologies. Overall, (-)-epicatechin solubility varies widely among the studied solvents but only slightly within the experimental temperature range. Solvents in ascending order according to (-)-epicatechin solubility are water < Gly + water < 13PD + water < DES2 + water < DES1 + water. The solubility of (-)-epicatechin is significantly enhanced by introducing choline chloride into the investigated hydrogen-bond donors (HBDs) at a molar ratio of 1:3, accompanied by 25 wt % water. Perturbed-chain statistical associating fluid theory (PC-SAFT) solubility calculations were in quantitative agreement with experimental data.
dc.fuente.origenWOS
dc.identifier.doi10.1021/acs.jced.4c00448
dc.identifier.eissn1520-5134
dc.identifier.issn0021-9568
dc.identifier.urihttps://doi.org/10.1021/acs.jced.4c00448
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89841
dc.identifier.wosidWOS:001346350500001
dc.issue.numero11
dc.language.isoen
dc.pagina.final4205
dc.pagina.inicio4197
dc.revistaJournal of chemical and engineering data
dc.rightsacceso restringido
dc.title(-)-Epicatechin Solubility in Aqueous Mixtures of Eutectic Solvents and Their Constituents
dc.typeartículo
dc.volumen69
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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