CYCLIC THROMBOCYTOPENIA OF APPARENT AUTOIMMUNE ETIOLOGY

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dc.contributor.authorMENITOVE, JE
dc.contributor.authorPEREIRA, J
dc.contributor.authorHOFFMAN, R
dc.contributor.authorANDERSON, T
dc.contributor.authorFRIED, W
dc.contributor.authorASTER, RH
dc.date.accessioned2025-01-23T19:23:59Z
dc.date.available2025-01-23T19:23:59Z
dc.date.issued1989
dc.description.abstractSerial studies were performed in two patients with cyclic thrombocytopenia to investigate the pathogenesis of this disorder. Mean life span of autologous platelets when platelet levels were declining was subnormal (2.4 and 0.8 days), and megakaryocytes were abundant in the bone marrow during thrombocytopenia. Megakaryocyte colony-stimulating activity could not be detected in the serum of either patient at any point of their cycles. In each patient, total platelet-associated IgG varied inversely with platelet levels. Surface platelet-associated IgG was measured only in patient 2 and was significantly elevated (> 1,280 IgG molecules per platelet) at all stages of the cycle, even durig thrombocytosis. However, the highest values were observed during thrombocytopenia. Platelet-bindable IgG in plasma declined to normal immediately before platelet levels began to rise. IgG eluted from the platelets of this patient reacted strongly with autologous and homologous platelets in contrast to a "mock eluate" prepared from platelets of a normal subject. The eluate from the patient''s platelets reacted strongly with immobilized autologous and homologous glycoprotein IIb/IIIa complex and weakly with GPIb but not with isolated GPIIIa alone. In each patient the decline in platelet levels was significantly delayed following administration of intravenous gamma globulin 0.4 g/kg body weight for five days. These findings suggest that platelet-reactive autoantibodies are of pathogenic significance in some patients with cyclic thrombocytopenia.
dc.fuente.origenWOS
dc.identifier.eissn1528-0020
dc.identifier.issn0006-4971
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99292
dc.identifier.wosidWOS:A1989U433100023
dc.issue.numero6
dc.language.isoen
dc.pagina.final1569
dc.pagina.inicio1561
dc.revistaBlood
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCYCLIC THROMBOCYTOPENIA OF APPARENT AUTOIMMUNE ETIOLOGY
dc.typeartículo
dc.volumen73
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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