Gut mucosal atrophy after a short enteral pasting period in critically ill patients

Simple item page
dc.contributor.authorHernandez, G
dc.contributor.authorVelasco, N
dc.contributor.authorWainstein, C
dc.contributor.authorCastillo, L
dc.contributor.authorBugedo, G
dc.contributor.authorMaiz, A
dc.contributor.authorLopez, F
dc.contributor.authorGuzman, S
dc.contributor.authorVargas, C
dc.date.accessioned2025-01-21T01:32:02Z
dc.date.available2025-01-21T01:32:02Z
dc.date.issued1999
dc.description.abstractPurpose: The purpose of this study was to evaluate the presence of gut mucosal atrophy and changes in mucosal permeability in critically ill patients after a short fasting period.
dc.description.abstractMaterials and Methods: Fifteen critically ill patients underwent a period of enteral fasting of at least 4 days (mean 7.8 days). We took the following measurements the day before initiating enteral nutrition: indirect calorimetry, serum albumin, prealbumin, and lymphocyte count. We also performed a duodenal endoscopic biopsy with histopathological and mucosal morphometric analysis including villus height and crypt depth. The lactulose-mannitol test was performed to assess gut permeability, A total of 28 healthy volunteers served as controls for duodenal biopsy or lactulose-mannitol test. Clinical data, such as length of fasting, severity score, and previous parenteral nutritional support, were recorded,
dc.description.abstractResults: We found gut mucosal atrophy, expressed as a decrease in villus height and crypt depth, in patients compared with controls. The patients also exhibited an abnormal lactulose-mannitol test. Morphometric changes did not correlate with permeability. Further, we found no correlation between the results of the lactulose-mannitol test and of mucosal morphometry with clinical data.
dc.description.abstractConclusions: We found that a short period of enteral fasting was associated with significant duodenal mucosal atrophy and abnormal gut permeability in critically ill patients. Copyright (C) 1999 by W.B, Saunders Company.
dc.fuente.origenWOS
dc.identifier.issn0883-9441
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97192
dc.identifier.wosidWOS:000080732700003
dc.issue.numero2
dc.language.isoen
dc.pagina.final77
dc.pagina.inicio73
dc.revistaJournal of critical care
dc.rightsacceso restringido
dc.subject.ods02 Zero Hunger
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleGut mucosal atrophy after a short enteral pasting period in critically ill patients
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas