Maximizing treatment efficacy through patient stratification in neuropathic pain trials

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dc.contributor.authorBaron, Ralf
dc.contributor.authorDickenson, Anthony H.
dc.contributor.authorCalvo, Margarita
dc.contributor.authorDib-Hajj, Sulayman D.
dc.contributor.authorBennett, David L.
dc.date.accessioned2025-01-20T20:20:22Z
dc.date.available2025-01-20T20:20:22Z
dc.date.issued2023
dc.description.abstractDespite substantial research advances, treatment of neuropathic pain remains inadequate and responses to treatment are highly variable. In this Perspective, the authors argue that rational stratification of patients with neuropathic pain will aid identification of subgroups of patients who will benefit most from a given treatment.
dc.description.abstractTreatment of neuropathic pain remains inadequate despite the elucidation of multiple pathophysiological mechanisms and the development of promising therapeutic compounds. The lack of success in translating knowledge into clinical practice has discouraged pharmaceutical companies from investing in pain medicine; however, new patient stratification approaches could help bridge the translation gap and develop individualized therapeutic approaches. As we highlight in this article, subgrouping of patients according to sensory profiles and other baseline characteristics could aid the prediction of treatment success. Furthermore, novel outcome measures have been developed for patients with neuropathic pain. The extent to which sensory profiles and outcome measures can be employed in routine clinical practice and clinical trials and across distinct neuropathic pain aetiologies is yet to be determined. Improvements in animal models, drawing on our knowledge of human pain, and robust public-private partnerships will be needed to pave the way to innovative and effective pain medicine in the future.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41582-022-00741-7
dc.identifier.eissn1759-4766
dc.identifier.issn1759-4758
dc.identifier.urihttps://doi.org/10.1038/s41582-022-00741-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92575
dc.identifier.wosidWOS:000885215200002
dc.issue.numero1
dc.language.isoen
dc.pagina.final64
dc.pagina.inicio53
dc.revistaNature reviews neurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaximizing treatment efficacy through patient stratification in neuropathic pain trials
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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