RELEASE OF ENDOGENOUS CATECHOLAMINES FROM THE STRIATUM AND BED NUCLEUS OF STRIA TERMINALIS EVOKED BY POTASSIUM AND N-METHYL-D-ASPARTATE - IN-VITRO MICRODIALYSIS STUDIES

Simple item page
dc.contributor.authorALIAGA, E
dc.contributor.authorBUSTOS, G
dc.contributor.authorGYSLING, K
dc.date.accessioned2025-01-21T01:35:05Z
dc.date.available2025-01-21T01:35:05Z
dc.date.issued1995
dc.description.abstractInduced release of endogenous dopamine and noradrenaline from coronal slices containing the striatum and the bed nucleus of the stria terminalis, respectively, was studied by means of in vitro microdialysis, A Ca+2-dependent and reserpine-sensitive K+-induced release of catecholamines was detected in both nuclei, We confirmed that N-methyl-D-aspartate (2.5 and 5.0 mM in the dialysis perfusion solution) induces the release of dopamine from the striatum, and this effect was blocked by prior dialysis perfusion with 500 mu M MK-801, a noncompetitive N-methyl-D-aspartate receptor antagonist, Infusion of N-methyl-D-aspartate (1-10 mM) or glutamate through the dialysis probe did not produce any detectable modification in the extracellular levels of noradrenaline in the bed nucleus of the stria terminalis, In addition, perfusion with D-serine (100 mu M) alone or in the presence of desipramine (10 mu M), resulted in a slight increase in extracellular noradrenaline in the bed nucleus of the stria terminalis. However, N-methyl-D-aspartate in the presence of D-serine and desipramine produced a marked increase in extracellular noradrenaline from the bed nucleus of the stria terminalis. These results indicate that N-methyl-D-aspartate receptors might regulate the release of noradrenaline from the bed nucleus of the stria terminalis as is the case of dopamine release in the striatum, The in vitro microdialysis seems to be a suitable complement to the in vivo microdialysis for the study of catecholamine release in discrete regions of the central nervous system and its local regulation by excitatory amino acid receptors. (C) 1995 Wiley Liss, Inc.
dc.fuente.origenWOS
dc.identifier.issn0360-4012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97639
dc.identifier.wosidWOS:A1995QH41700009
dc.issue.numero1
dc.language.isoen
dc.pagina.final98
dc.pagina.inicio89
dc.revistaJournal of neuroscience research
dc.rightsacceso restringido
dc.subjectDOPAMINE
dc.subjectNORADRENALINE
dc.subjectGLUTAMATE RECEPTORS
dc.subjectIN VITRO MICRODIALYSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRELEASE OF ENDOGENOUS CATECHOLAMINES FROM THE STRIATUM AND BED NUCLEUS OF STRIA TERMINALIS EVOKED BY POTASSIUM AND N-METHYL-D-ASPARTATE - IN-VITRO MICRODIALYSIS STUDIES
dc.typeartículo
dc.volumen40
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas