EPIDERMAL GROWTH-FACTOR INHIBITS CYTOSKELETON-RELATED CHANGES IN THE SURFACE OF PARIETAL-CELLS

Simple item page
dc.contributor.authorGONZALEZ, A
dc.contributor.authorGARRIDO, J
dc.contributor.authorVIAL, JD
dc.date.accessioned2025-01-23T19:44:16Z
dc.date.available2025-01-23T19:44:16Z
dc.date.issued1981
dc.description.abstractThe effect of epidermal growth factor (EGF) on gastric acid secretion was correlated with the morphological changes of the apical pole of rat parietal cells studied by transmission electron microscopy. Gastric acid secretion was stimulated by histamine, carbachol, pentagastrin and insulin-induced hypoglycemia and estimated by continuous recording of pH variations of gastric luminal perfusate. EGF inhibits acid secretion in these conditions. The action of the hormone also results in the arrest or reversal of the changes in shape undergone by parietal cells as they go into secretion. In view of the evidence involving cytoskeletal elements in the generation of these structural alterations, the action of EGF on gastric acid secretion may be a consequence of a general effect of this hormone on cytoskeletal function.
dc.fuente.origenWOS
dc.identifier.eissn1540-8140
dc.identifier.issn0021-9525
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99991
dc.identifier.wosidWOS:A1981KV90700014
dc.issue.numero1
dc.language.isoen
dc.pagina.final114
dc.pagina.inicio108
dc.revistaJournal of cell biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEPIDERMAL GROWTH-FACTOR INHIBITS CYTOSKELETON-RELATED CHANGES IN THE SURFACE OF PARIETAL-CELLS
dc.typeartículo
dc.volumen88
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas