Fractional adaptive observer for variable structure high cell density fed-batch cultures

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dc.catalogadorvdr
dc.contributor.authorBárzaga-Martell, Lisbel
dc.contributor.authorAguila-Camacho, Norelys
dc.contributor.authorIbáñez Espinel, Francisco
dc.contributor.authorDuarte-Mermoud, Manuel
dc.contributor.authorSaa Higuera, Pedro Andrés E.
dc.contributor.authorPérez C., José Ricardo
dc.date.accessioned2025-03-06T19:36:27Z
dc.date.available2025-03-06T19:36:27Z
dc.date.issued2024
dc.description.abstractThis paper presents the design and application of a fractional order asymptotic adaptive observer coupled to an adaptive controller for the robust operation of high-cell density cultures in fed-batch mode. The control goal is to maximize biomass productivity by controlling the culture's estimated specific growth rate. Since the specific growth rate cannot be measured, a fractional order asymptotic adaptive observer is proposed, based on the equivalent integer order asymptotic observer proposed before. Simulations are performed to validate the observer and controller, under the assumption that the system is in the oxidative regime under aerobic conditions. Obtained results show that, in close loop operation, the fractional adaptive observer behaves better than the integer order observer in the presence of measurement noise. For fractional orders of the observer in the range α G [0.6,0.8], it was observed a 51.71% increase in biomass concentration, compared to the biomass obtained with the classic integer-order observer. Furthermore, the controlled system reaches very low ethanol concentrations (< 1 grams per liter), which is desirable in this process.
dc.fechaingreso.objetodigital2025-03-06
dc.format.extent6 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.ifacol.2024.08.163
dc.identifier.issn2405-8963
dc.identifier.scopusidSCOPUS_ID:85203082950
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102414
dc.identifier.urihttps://doi.org/10.1016/j.ifacol.2024.08.163
dc.identifier.wosidWOS:001302134200007
dc.information.autorucEscuela de Ingeniería; Ibáñez Espinel, Francisco; 0000-0002-5626-7615; 1071066
dc.information.autorucEscuela de Ingeniería; Saa Higuera, Pedro Andrés E.; 0000-0002-1659-9041; 162204
dc.information.autorucEscuela de Ingeniería; Pérez C., José Ricardo; 0000-0002-1278-7782; 100130
dc.issue.numero12
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final42
dc.pagina.inicio37
dc.publisherELSEVIER
dc.revistaIFAC-PapersOnLine
dc.rightsacceso restringido
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdaptive control
dc.subjectFractional Asymptotic observer
dc.subjectHigh-cell density cultures (HCDC)
dc.subjectOverflow metabolism
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.subject.ods09 Industry, innovation and infrastructure
dc.subject.odspa09 Industria, innovación e infraestructura
dc.titleFractional adaptive observer for variable structure high cell density fed-batch cultures
dc.typeartículo
dc.volumen58
sipa.codpersvinculados1071066
sipa.codpersvinculados162204
sipa.codpersvinculados100130
sipa.trazabilidadSCOPUS;2024-09-15
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