Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course

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dc.contributor.authorLombardi, Raul
dc.contributor.authorFerreiro, Alejandro
dc.contributor.authorPonce, Daniela
dc.contributor.authorClaure-Del Granado, Rolando
dc.contributor.authorAroca, Gustavo
dc.contributor.authorVenegas, Yanissa
dc.contributor.authorPereira, Mariana
dc.contributor.authorChavez-Iniguez, Jonathan
dc.contributor.authorRojas, Nelson
dc.contributor.authorVilla, Ana
dc.contributor.authorColombo, Marcos
dc.contributor.authorCarlino, Cristina
dc.contributor.authorGuimaraes, Caio
dc.contributor.authorYounes-Ibrahim, Mauricio
dc.contributor.authorMaria Rizo, Lilia
dc.contributor.authorGuzman, Gisselle
dc.contributor.authorVarela, Carlos
dc.contributor.authorRosa-Diez, Guillermo
dc.contributor.authorJaniques, Diego
dc.contributor.authorAyala, Roger
dc.contributor.authorCoronel, Galo
dc.contributor.authorRoessler, Eric
dc.contributor.authorAmor, Serena
dc.contributor.authorOsorio, Washington
dc.contributor.authorRivas, Natalia
dc.contributor.authorPereira, Benedito
dc.contributor.authorde Azevedo, Caroline
dc.contributor.authorFlores, Adriana
dc.contributor.authorUbillo, Jose
dc.contributor.authorRano, Julieta
dc.contributor.authorYu, Luis
dc.contributor.authorBurdmann, Emmanuel A.
dc.contributor.authorRodriguez, Luis
dc.contributor.authorGalagarza-Gutierrez, Gianny
dc.contributor.authorCuritomay-Cruz, Jesus
dc.date.accessioned2025-01-20T21:08:54Z
dc.date.available2025-01-20T21:08:54Z
dc.date.issued2022
dc.description.abstractThe Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54-74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.
dc.description.funderSLANH
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0261764
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0261764
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93500
dc.identifier.wosidWOS:000779379600030
dc.issue.numero1
dc.language.isoen
dc.revistaPlos one
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLatin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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