The autonomous axon: a model based on local synthesis of proteins

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dc.contributor.authorAlvarez, J
dc.date.accessioned2025-01-21T01:31:02Z
dc.date.available2025-01-21T01:31:02Z
dc.date.issued2001
dc.description.abstractIn the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The 'autonomous axon' proposed here negates in turn transport of proteins, and asserts (i) local synthesis of axoplasmic proteins, corner stone of this model, (ii) existence of internal programs in axon and terminals, (iii) external control of programs resulting in local regulation of phenotype of axons and terminals, hence they are autonomous from perikarya; (iv) participation of perikarya through the fast transport in setting up the axonal programs but not in their immediate regulation. The word merotrophism (meros meaning part) denotes post-transcriptional regulation of phenotype of restricted regions of a cell. We surmise that merotrophism is at the base of many plastic phenomena.
dc.fuente.origenWOS
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96964
dc.identifier.wosidWOS:000171382700009
dc.issue.numero2
dc.language.isoen
dc.pagina.final109
dc.pagina.inicio103
dc.revistaBiological research
dc.rightsacceso restringido
dc.subjectplasticity
dc.subjectregeneration
dc.subjectSchwann cell
dc.subjectslow transport
dc.subjectsprouting
dc.subjecttrophism
dc.subjectWld(s)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe autonomous axon: a model based on local synthesis of proteins
dc.typeartículo
dc.volumen34
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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