Immune System Alterations by Aldosterone During Hypertension: From Clinical Observations to Genomic and Non-Genomic Mechanisms Leading to Vascular Damage

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dc.contributor.authorMunoz-Durango, N.
dc.contributor.authorBarake, M. F.
dc.contributor.authorLetelier, N. A.
dc.contributor.authorCampino, C.
dc.contributor.authorFardella, C. E.
dc.contributor.authorKalergis, A. M.
dc.date.accessioned2025-01-24T00:09:22Z
dc.date.available2025-01-24T00:09:22Z
dc.date.issued2013
dc.description.abstractHypertension is traditionally considered a disease in which elevated blood pressure contributes to inflammation and activation of the immune system, leading to cardiovascular injury and end-organ damage. Here, we discuss the effects of aldosterone on the immune system and aldosterone's contribution to vascular pathogenesis. Studies in human have suggested a broader role for aldosterone, beyond elevating blood pressure. Recent clinical data support the notion that aldosterone can directly alter the function of the immune system and cause vascular-damaging inflammation. Clinical observations have been reproduced in experimental models of hypertension, further supporting the idea that an aberrant immune response contributes to the onset of hypertension. Such studies have shown that myeloid cells are required to induce the disease and IL-17-producing CD4(+) T cells may contribute to maintaining aldosterone-mediated hypertension. In addition, regulatory T cells diminish the inflammatory damage caused by aldosterone during hypertension. This is a very active area of research that could lead to new therapeutic targets for treating hypertension.
dc.fuente.origenWOS
dc.identifier.eissn1875-5666
dc.identifier.issn1566-5240
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101987
dc.identifier.wosidWOS:000320507400015
dc.issue.numero6
dc.language.isoen
dc.pagina.final1046
dc.pagina.inicio1035
dc.revistaCurrent molecular medicine
dc.rightsacceso restringido
dc.subjectAldosterone
dc.subjectGPR30
dc.subjecthypertension
dc.subjectinflammation
dc.subjectmineralocorticoid receptor
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImmune System Alterations by Aldosterone During Hypertension: From Clinical Observations to Genomic and Non-Genomic Mechanisms Leading to Vascular Damage
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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