NADPH-d positive neurons in the developing somatosensory cortex of the rat: effects of early and late environmental enrichment

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dc.contributor.authorFernandez, V
dc.contributor.authorBravo, H
dc.contributor.authorSanhueza, M
dc.contributor.authorInzunza, O
dc.date.accessioned2024-01-10T12:06:50Z
dc.date.available2024-01-10T12:06:50Z
dc.date.issued1998
dc.description.abstractThe effects of environmental enrichment upon the topographic arrangement of NADPH diaphorase-positive neurons (NADPH-d(+) neurons) was studied in the somatosensory cortex of 56 Sprague-Dawley albino rats during early stages of development (18th, 24th, 30th and 60th postnatal days). This diaphorase is easily demonstrable, providing a convenient marker for quantitative studies. Environmental enrichment diminished the number of NADPH-d(+) neurons and exerted its maximal influence during lactation, a time of exceptional cortical susceptibility. This implies that the magnitude of such effects on the density of NADPH-d(+) neurons is age-dependent. Furthermore, it was found that the experience-dependent cortical changes persisted after a subsequent period without environmental stimulation. The effects of early environmental enrichment did not occur uniformly throughout the cerebral hemispheres but, instead, such effects were maximal in the latero-ventral sector of the cerebral cortex where a dramatic reduction in the number of NADPH-d(+) neurons was observed. Particularly striking was the existence of a latero-medial sequence of NADPH-d(+) neurons in the infragranular layer and a reversed distribution of labeled cells, in the supragranular layer. Both ontogenetic sequences of NADPH-d(+) neurons remained unchanged during postnatal development in controls and enriched subjects (18th-60th postnatal days). (C) 1998 Elsevier Science B.V.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0165-3806(98)00037-6
dc.identifier.issn0165-3806
dc.identifier.pubmedidMEDLINE:9593955
dc.identifier.urihttps://doi.org/10.1016/S0165-3806(98)00037-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76212
dc.identifier.wosidWOS:000074009600015
dc.information.autorucMedicina;Bravo H;S/I;99029
dc.information.autorucMedicina;Inzunza O;S/I;99951
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final307
dc.pagina.inicio299
dc.publisherELSEVIER SCIENCE BV
dc.revistaDEVELOPMENTAL BRAIN RESEARCH
dc.rightsacceso restringido
dc.subjectnicotinamide adenine dinucleotide phosphate-diaphorase neuron
dc.subjectenvironmental enrichment
dc.subjectpersistence
dc.subjecthistogenetic gradient
dc.subjectsomatosensory cortex
dc.subjectrat
dc.subjectCENTRAL-NERVOUS-SYSTEM
dc.subjectNITRIC-OXIDE
dc.subjectCEREBRAL-CORTEX
dc.subjectMOTOR CORTEX
dc.subjectINFARCTION
dc.subjectNEOCORTEX
dc.subjectGROWTH
dc.subjectCELLS
dc.subjectGOLGI
dc.subjectGRADIENTS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNADPH-d positive neurons in the developing somatosensory cortex of the rat: effects of early and late environmental enrichment
dc.typeartículo
dc.volumen107
sipa.codpersvinculados99029
sipa.codpersvinculados99951
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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