Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors

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dc.contributor.authorMontague, Samantha J.
dc.contributor.authorPatel, Pushpa
dc.contributor.authorMartin, Eleyna M.
dc.contributor.authorSlater, Alexandre
dc.contributor.authorQuintanilla, Lourdes Garcia
dc.contributor.authorPerrella, Gina
dc.contributor.authorKardeby, Caroline
dc.contributor.authorNagy, Magdolna
dc.contributor.authorMezzano, Diego
dc.contributor.authorMendes, Paula M.
dc.contributor.authorWatson, Steve P.
dc.date.accessioned2025-01-20T22:14:28Z
dc.date.available2025-01-20T22:14:28Z
dc.date.issued2021
dc.description.abstractCharge interactions play a critical role in the activation of the innate immune system by damage- and pathogen-associated molecular pattern receptors. The ability of these receptors to recognize a wide spectrum of ligands through a common mechanism is critical in host defense. In this article, we argue that platelet glycoprotein receptors that signal through conserved tyrosine-based motifs function as pattern recognition receptors (PRRs) for charged endogenous and exogenous ligands, including sulfated polysaccharides, charged proteins and nanoparticles. This is exemplified by GPVI, CLEC-2 and PEAR1 which are activated by a wide spectrum of endogenous and exogenous ligands, including diesel exhaust particles, sulfated polysaccharides and charged surfaces. We propose that this mechanism has evolved to drive rapid activation of platelets at sites of injury, but that under some conditions it can drive occlusive thrombosis, for example, when blood comes into contact with infectious agents or toxins. In this Opinion Article, we discuss mechanisms behind charge-mediated platelet activation and opportunities for designing nanoparticles and related agents such as dendrimers as novel antithrombotics.
dc.fuente.origenWOS
dc.identifier.doi10.1080/09537104.2021.1945571
dc.identifier.eissn1369-1635
dc.identifier.issn0953-7104
dc.identifier.urihttps://doi.org/10.1080/09537104.2021.1945571
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94482
dc.identifier.wosidWOS:000673153200001
dc.issue.numero8
dc.language.isoen
dc.pagina.final1030
dc.pagina.inicio1018
dc.revistaPlatelets
dc.rightsacceso restringido
dc.subjectCLEC-2
dc.subjectGPVI
dc.subjectnanoparticles
dc.subjectpattern recognition receptors
dc.subjectPEAR1
dc.subjectplatelets
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlatelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors
dc.typeartículo
dc.volumen32
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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