Six-Minute Walking Distance in Women with COPD

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dc.contributor.authorde Torres, Juan P.
dc.contributor.authorCasanova, Ciro
dc.contributor.authorCote, Claudia G.
dc.contributor.authorLopez, Maria V.
dc.contributor.authorDiaz, Orlando
dc.contributor.authorMaria Marin, Jose
dc.contributor.authorPinto Plata, Victor
dc.contributor.authorMontes de Oca, Maria
dc.contributor.authorAguirre Jaime, Armando
dc.contributor.authorCelli, Bartolome R.
dc.date.accessioned2024-01-10T13:43:35Z
dc.date.available2024-01-10T13:43:35Z
dc.date.issued2011
dc.description.abstractBackground: The 6-minute walk distance (6MWD) has been useful in the evaluation of men with COPD. Little is known about 6MWD in women with the disease. Objectives: Using healthy women as a reference, to evaluate the factors that help determine 6MWD in women with COPD. To explore if the 350 meters threshold differentiates survival in women as it does in men. Methods: Healthy women (n = 164) and with COPD (n = 223) were included in the study. Age, pack-years history, smoking status, comorbidities (Charlson Index), BMI, MRC dyspnea, spirometry and 6MWD were recorded in all participants and PaO2 and IC/TLC in COPD women. The patients were prospectively followed and deaths registered. Factors predicting 6MWD were determined by multiple regression analysis. ROC analysis was used to calculate the best threshold value for the 6MWD with mortality as gold standard. Kaplan-Meier curves compared survival of patients that walked more or less than 350 m by age categories. Results: The 6MWD is decreased in women with COPD. Values decrease with age and GOLD stages. Age, BMI, smoking status, comorbidities, MRC and FEV1% are statistical significant predictors of 6MWD. A 350 m cut-off value has a good sensitivity and specificity to predict (73% and 80% respectively) and differentiate survival (p < 0.001 for log rank comparisons) in these patients. Conclusions: In women with COPD, the 6MWD decreases with age and GOLD stages. A 350 m distance is a valid threshold to differentiate survival. Further studies in different settings should confirm our findings.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/15412555.2011.589870
dc.identifier.eissn1541-2563
dc.identifier.issn1541-2555
dc.identifier.pubmedidMEDLINE:21767075
dc.identifier.urihttps://doi.org/10.3109/15412555.2011.589870
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78685
dc.identifier.wosidWOS:000294176000009
dc.information.autorucMedicina;Diaz O ;S/I;78564
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final305
dc.pagina.inicio300
dc.publisherTAYLOR & FRANCIS INC
dc.revistaCOPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
dc.rightsacceso restringido
dc.subjectWomen
dc.subjectCOPD
dc.subject6MWD
dc.subjectGender
dc.subjectVALIDATION
dc.subjectMORTALITY
dc.subjectCAPACITY
dc.subjectDYSPNEA
dc.subjectGENDER
dc.subjectINDEX
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSix-Minute Walking Distance in Women with COPD
dc.typeartículo
dc.volumen8
sipa.codpersvinculados78564
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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