Combined Administration of Andrographolide and Angiotensin- (1-7) Synergically Increases the Muscle Function and Strength in Aged Mice

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dc.contributor.authorAbrigo, Johanna
dc.contributor.authorSimon, Felipe
dc.contributor.authorCabrera, Daniel
dc.contributor.authorVilos, Cristian
dc.contributor.authorCabello-Verrugio, Claudio
dc.date.accessioned2025-01-20T21:03:54Z
dc.date.available2025-01-20T21:03:54Z
dc.date.issued2022
dc.description.abstractBackground: Sarcopenia is a progressive and generalized skeletal muscle disorder characterized by muscle weakness, loss of muscle mass, and decline in the capacity of force generation. Aging can cause sarcopenia. Several therapeutic strategies have been evaluated to prevent or alleviate this disorder. One of them is angiotensin 1-7 [Ang-(1-7)], an anti-atrophic peptide for skeletal muscles that regulates decreased muscle mass for several causes, including aging. Another regulator of muscle mass and function is andrographolide, a bicyclic diterpenoid lactone that decreases the nuclear factor kappa B (NF-kappa B) signaling and attenuates the severity of some muscle diseases. Objective: Evaluate the effect of combined administration of Ang-(1-7) with andrographolide on the physical performance, muscle strength, and fiber ' s diameter in a murine model of sarcopenia by aging. Methods: Aged male mice of the C57BL/6J strain were treated with Andrographolide, Ang-(1-7), or combined for three months. The physical performance, muscle strength, and fiber ' s diameter were measured. Results: The results showed that aged mice (24 months old) treated with Ang-(1-7) or Andrographolide improved their performance on a treadmill test, muscle strength, and their fiber ' s diameter compared to aged mice without treatment. The combined administration of Ang-(1-7) with andrographolide to aged mice has an enhanced synergically effect on physical performance, muscle strength, and fiber ' s diameter. Conclusion: Our results indicated that in aged mice, the effects of andrographolide and Ang-(1-7) on muscle function, strength, and fiber ' s diameter are potentiated.
dc.fuente.origenWOS
dc.identifier.doi10.2174/1566524021666211207112106
dc.identifier.eissn1875-5666
dc.identifier.issn1566-5240
dc.identifier.urihttps://doi.org/10.2174/1566524021666211207112106
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93191
dc.identifier.wosidWOS:000834105200007
dc.issue.numero10
dc.language.isoen
dc.pagina.final918
dc.pagina.inicio908
dc.revistaCurrent molecular medicine
dc.rightsacceso restringido
dc.subjectSarcopenia
dc.subjectrenin-angiotensin system
dc.subjectweakness
dc.subjectphysical performance
dc.subjectMuscle Function
dc.subjectAngiotensin-(1-7)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCombined Administration of Andrographolide and Angiotensin- (1-7) Synergically Increases the Muscle Function and Strength in Aged Mice
dc.typeartículo
dc.volumen22
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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