Involvement of A2B adenosine receptors as anti-inflammatory in gestational diabesity.

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dc.contributor.authorCabalin, Carolina
dc.date.accessioned2023-05-19T20:50:02Z
dc.date.available2023-05-19T20:50:02Z
dc.date.issued2019
dc.description.abstractPregnant women that are obese may develop gestational diabetes mellitus (GDM) configuring a new metabolic condition referred to as gestational diabesity. The metabolic alterations seen in gestational diabesity include a combination of an exacerbated pro-inflammatory state and fetoplacental endothelial dysfunction. Also, gestational diabesity associates with supra-physiological extracellular concentration of adenosine in the foetoplacental blood. Since adenosine plays a central role in the inflammatory response in GDM and obesity, it is likely that this nucleoside will play a similar role in gestational diabesity. However, the effect of adenosine in the foetoplacental vasculature in this condition is not yet addressed. Adenosine exerts its biological actions via four adenosine receptors. Activation of A(2B) adenosine receptors (A(2B)AR) subtype associates with an anti-inflammatory response in several tissue and diseases. In tissues from pregnant women with GDM, there is an overexpression of A(2B)AR, and higher mRNA expression of ADORA2B (for A(2B)AR) was shown to correlate with hyperglycaemia and oxidative stress. A(2B)AR shows low affinity for adenosine (micromolar) and its activation results in triggering intracellular signalling cascades lowering the inflammatory response. This phenomenon requires a high level of extracellular adenosine in diseases of pregnancy such as GDM or gestational diabesity. In this review, we focused on the role of A(2B)AR involvement in the biological actions of adenosine on inflammation in the foetoplacental vasculature in gestational diabesity. Some factors including oxidative stress and hypoxia in this phenomenon are discussed.
dc.fechaingreso.objetodigital2024-12-14
dc.fuente.origenORCID-mayo23
dc.identifier.doi10.1016/j.mam.2019.01.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70134
dc.identifier.wosidWOS:000467827600005
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final39
dc.pagina.inicio31
dc.revistaMolecular Aspects of Medicine
dc.rightsacceso restringido
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInvolvement of A2B adenosine receptors as anti-inflammatory in gestational diabesity.es_ES
dc.typeartículo
dc.volumenVol. 66
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