NATURAL-RESISTANCE TO EFFECTS OF MORPHINE IN OCTODON-DEGUS A SOUTH-AMERICAN RODENT

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dc.contributor.authorPAEILE, C
dc.contributor.authorCONTRERAS, S
dc.contributor.authorMIRANDA, H
dc.contributor.authorVILLANUEVA, L
dc.contributor.authorBUSTOS, E
dc.date.accessioned2025-01-23T19:43:48Z
dc.date.available2025-01-23T19:43:48Z
dc.date.issued1984
dc.description.abstractO. degus, a South American caviomorph, presents a natural resistance to some effects of morphine. None of the doses of morphine (i.v.) employed produced a significant modification of respiration rate. The administration of morphine leu-enkephalin and .beta.-endorphin to isolated O. degus vas deferens did not significantly change electrically-induced muscular twitches. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified in EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.
dc.fuente.origenWOS
dc.identifier.issn0193-0818
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99825
dc.identifier.wosidWOS:A1984ST93600002
dc.issue.numero1
dc.language.isoen
dc.pagina.final22
dc.pagina.inicio11
dc.revistaResearch communications in substances of abuse
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNATURAL-RESISTANCE TO EFFECTS OF MORPHINE IN OCTODON-DEGUS A SOUTH-AMERICAN RODENT
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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