Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity

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dc.catalogadorjwg
dc.contributor.authorMattar, P.
dc.contributor.authorUribe Cerda, S.
dc.contributor.authorPezoa, C.
dc.contributor.authorGuarnieri, T.
dc.contributor.authorKotz, C. M.
dc.contributor.authorTeske, J. A.
dc.contributor.authorMorselli, E.
dc.contributor.authorPerez Leighton Claudio Esteban
dc.date.accessioned2024-11-14T14:48:46Z
dc.date.available2024-11-14T14:48:46Z
dc.date.issued2022
dc.description.abstractThe orexin peptides promote hedonic intake and other reward behaviors through different brain sites. The opioid dynorphin peptides are co-released with orexin peptides but block their effects on reward in the ventral tegmental area (VTA). We previously showed that in the paraventricular hypothalamic nucleus (PVN), dynorphin and not orexin peptides enhance hedonic intake, suggesting they have brain-site-specific effects. Obesity alters the expression of orexin and dynorphin receptors, but whether their expression across different brain sites is important to hedonic intake is unclear. We hypothesized that hedonic intake is regulated by orexin and dynorphin peptides in PVN and that hedonic intake in obesity correlates with expression of their receptors. Here we show that in mice, injection of DYN-A(1-13) (an opioid dynorphin peptide) in the PVN enhanced hedonic intake, whereas in the VTA, injection of OXA (orexin-A, an orexin peptide) enhanced hedonic intake. In PVN, OXA blunted the increase in hedonic intake caused by DYN-A(1-13). In PVN, injection of norBNI (opioid receptor antagonist) reduced hedonic intake but a subsequent OXA injection failed to increase hedonic intake, suggesting that OXA activity in PVN is not influenced by endogenous opioid activity. In the PVN, DYN-A(1-13) increased the intake of the less-preferred food in a two-food choice task. In obese mice fed a cafeteria diet, orexin 1 receptor mRNA across brain sites involved in hedonic intake correlated with fat preference but not caloric intake. Together, these data support that orexin and dynorphin peptides regulate hedonic intake in an opposing manner with brain-site-specific effects.
dc.description.funderCONICYT FONDECYT
dc.description.funderNational Institutes of Health
dc.description.funderUnited States Department of Agriculture
dc.description.funderCONICYT-FONDECYT
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1080/1028415X.2020.1840049
dc.identifier.eissn1476-8305
dc.identifier.issn1028-415X
dc.identifier.pubmedidMEDLINE:33151127
dc.identifier.urihttps://doi.org/10.1080/1028415X.2020.1840049
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88551
dc.identifier.wosidWOS:000586097500001
dc.information.autorucFacultad de Ciencias Biológicas; Perez Leighton Claudio Esteban; 0000-0003-1817-6314; 126972
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaNUTRITIONAL NEUROSCIENCE
dc.rightsacceso restringido
dc.subjectOrexin
dc.subjecthypocretin
dc.subjectdynorphin
dc.subjectcafeteria diet
dc.subjecthypothalamus
dc.subjectobesity
dc.subjecthedonic intake
dc.subjectfood choice
dc.subjectfeeding behavior
dc.subjectfat
dc.subjectorexin 1 receptor
dc.subjectopioid receptors
dc.subjectNOR-BINALTORPHIMINE
dc.subjectFOOD-INTAKE
dc.subjectDYNORPHIN
dc.subjectDIET
dc.subjectRECEPTORS
dc.subjectBINDING
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBrain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity
dc.typeartículo
sipa.codpersvinculados126972
sipa.trazabilidadORCID;2024-11-11
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