Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic

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dc.contributor.authorMena, Juan
dc.contributor.authorTapia, Rodrigo
dc.contributor.authorVerdugo, Claudio
dc.contributor.authorAvendano, Luis
dc.contributor.authorParra-Castro, Paulina
dc.contributor.authorMedina, Rafael A.
dc.contributor.authorBarriga, Gonzalo
dc.contributor.authorNeira, Victor
dc.date.accessioned2025-01-20T22:05:28Z
dc.date.available2025-01-20T22:05:28Z
dc.date.issued2021
dc.description.abstractUnderstanding the diversity and circulation dynamics of seasonal influenza viruses is key to public health decision-making. The limited genetic information of pre-pandemic seasonal IAVs in Chile has made it difficult to accurately reconstruct the phylogenetic relationships of these viruses within the country. The objective of this study was to determine the genetic diversity of pre-pandemic human seasonal IAVs in Chile. We sequenced the complete genome of 42 historic IAV obtained between 1996 and 2007. The phylogeny was determined using HA sequences and complemented using other segments. Time-scale phylogenetic analyses revealed that the diversity of pre-pandemic human seasonal IAVs in Chile was influenced by continuous introductions of new A/H1N1 and A/H3N2 lineages and constant viral exchange between Chile and other countries every year. These results provide important knowledge about genetic diversity and evolutionary patterns of pre-pandemic human seasonal IAVs in Chile, which can help design optimal surveillance systems and prevention strategies. However, future studies with current sequences should be conducted.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-021-00795-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-021-00795-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94147
dc.identifier.wosidWOS:000714953500087
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCirculation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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