IS2aR, a computational tool to transform voxelized reference phantoms into patient-specific whole-body virtual CTs for peripheral dose estimation

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dc.contributor.authorMunoz-Hernandez, Isidora Sofia
dc.contributor.authorEspinoza, Ignacio
dc.contributor.authorLopez-Martinez, Ignacio N.
dc.contributor.authorSanchez-Nieto, Beatriz
dc.date.accessioned2025-01-20T17:21:05Z
dc.date.available2025-01-20T17:21:05Z
dc.date.issued2023
dc.description.abstractBackground: The risk of radiogenic cancer induction due to radiotherapy depends on the dose received by the patient's organs. Knowing the position of all organs is needed to assess this dose in a personalized way. However, radiotherapy planning computed tomography (pCT) scans contain truncated patient anatomy, limiting personalized dose evaluation. Purpose: To develop a simple and freely available computational tool that adapts an ICRP reference computational phantom to generate a patient-specific whole-body CT for peripheral dose computations. Methods: Various bone-segmentation methods were explored onto fifteen pCTs, and the one with the highest Sorensen-Dice coefficient was implemented. The reference phantom is registered to the pCT, obtaining a registration transform matrix, which is then applied to create the whole-body virtual CT. Additional validation involved a comparison of absorbed doses to organs delineated on both the pCT and the virtual CT. Results: A dedicated graphical user interface was designed and implemented to house the developed functions for i) selecting a registration region on which automatic bone segmentation and rigid registration will occur, ii) displaying the results of these processes under selectable views, and iii) exporting the final patient-specific whole-body CT. This software was termed IS2aR. The tested whole-body virtual CT generated by IS2aR fulfilled our requirements. Conclusions: IS2aR is a user-friendly computational software to create a personalized whole-body CT containing the original structures in the reference phantom. The personalized dose deposited in peripheral organs can be estimated further to assess second cancer induction risk in epidemiological studies.
dc.description.funderANID (FONDECYT)
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ejmp.2023.103183
dc.identifier.eissn1724-191X
dc.identifier.issn1120-1797
dc.identifier.urihttps://doi.org/10.1016/j.ejmp.2023.103183
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91446
dc.identifier.wosidWOS:001125346000001
dc.language.isoen
dc.revistaPhysica medica-european journal of medical physics
dc.rightsacceso restringido
dc.subjectRadiotherapy
dc.subjectWhole-body virtual CT
dc.subjectPeripheral dose estimation
dc.subjectImage processing
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIS2aR, a computational tool to transform voxelized reference phantoms into patient-specific whole-body virtual CTs for peripheral dose estimation
dc.typeartículo
dc.volumen116
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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