Susceptibility to express amphetamine locomotor sensitization correlates with dorsolateral striatum bursting activity and GABAergic synapses in the globus pallidus

Simple item page
dc.contributor.authorIgnacio Gatica, Rafael
dc.contributor.authorAguilar-Rivera, Marcelo
dc.contributor.authorHenny, Pablo
dc.contributor.authorAntonio Fuentealba, Jose
dc.date.accessioned2025-01-20T21:08:09Z
dc.date.available2025-01-20T21:08:09Z
dc.date.issued2022
dc.description.abstractRepeated psychostimulant administration results in behavioral sensitization, a process that is relevant in the early phases of drug addiction. Critically, behavioral sensitization is not observed in all subjects. Evidence shows that differential neuronal activity in the dorsolateral striatum (DLS) accompanies the expression of amphetamine (AMPH) locomotor sensitization. However, whether individual differences in DLS activity previous to AMPH administration can predict the expression of locomotor sensitization has not been assessed. Here, we examined DLS neuronal activity before and after repeated AMPH administration and related it to the susceptibility of rats to sensitize. For that, single-unit recordings on DLS medium spiny neurons (MSNs) were carried out in freely moving male Sprague Dawley rats during repeated AMPH administration. We also examined differences in neurostructure that could accompany sensitization. We quantified the density of the inhibitory postsynaptic marker gephyrin (Geph) in the entopeduncular nucleus (EP) and globus pallidus (GP). A higher burst firing and a lower percentage of correlation between MSNs post-Saline firing rate vs. locomotion predicted the expression of locomotor sensitization. Moreover, during the AMPH challenge, we observed that burst firing decreased in sensitized rats, in contrast to non-sensitized rats in which burst firing was maintained. Finally, a higher Geph density on GP but not EP was observed in non-sensitized rats after AMPH challenge. These results indicate that initial differences in DLS burst firing might underlie the susceptibility to express locomotor sensitization and suggest that the potentiation of dorsal striatum indirect pathway could be considered a protective mechanism to locomotor sensitization.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.brainresbull.2021.12.005
dc.identifier.eissn1873-2747
dc.identifier.issn0361-9230
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2021.12.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93460
dc.identifier.wosidWOS:000791810100003
dc.language.isoen
dc.pagina.final96
dc.pagina.inicio83
dc.revistaBrain research bulletin
dc.rightsacceso restringido
dc.subjectAmphetamine
dc.subjectBasal ganglia
dc.subjectDorsolateral striatum
dc.subjectIndividual differences
dc.subjectLocomotor sensitization
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSusceptibility to express amphetamine locomotor sensitization correlates with dorsolateral striatum bursting activity and GABAergic synapses in the globus pallidus
dc.typeartículo
dc.volumen179
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas