Expression of connexins during differentiation and regeneration of skeletal muscle

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dc.contributor.authorAraya, R
dc.contributor.authorEckardt, D
dc.contributor.authorMaxeiner, S
dc.contributor.authorKrüger, O
dc.contributor.authorTheis, M
dc.contributor.authorWillecke, K
dc.contributor.authorSáez, JC
dc.date.accessioned2025-01-21T01:07:22Z
dc.date.available2025-01-21T01:07:22Z
dc.date.issued2005
dc.description.abstractThe molecular mechanisms regulating skeletal muscle regeneration and differentiation are not well understood. We analyzed the expression of connexins (Cxs) 40, 43 and 45 in normal and regenerating tibialis anterior muscle and in primary cultures of differentiating myoblasts in adult and newborn mice, respectively. Cxs 45 and 43, but not 40, were strongly expressed in normal muscle and their expression was upregulated during regeneration. Furthermore, the functional role of Cx43 during differentiation and regeneration was examined after induced deletion of Cx43 in transgenic mice. In vivo, the inducible deletion of Cx43 delayed the formation of myofibers and prolonged the expression of myogenin during regeneration. In primary cultures of satellite cell-derived myoblasts, induced deletion of Cx43 led to decreased expression of myogenin and MyoD, dye coupling, creatine kinase activity and myoblast fusion. Thus, the expression of Cx45 and Cx43 is upregulated during skeletal muscle regeneration and Cx43 is required for normal myogenesis in vitro and adult muscle regeneration in vivo.
dc.fuente.origenWOS
dc.identifier.doi10.1242/jcs.01553
dc.identifier.eissn1477-9137
dc.identifier.issn0021-9533
dc.identifier.urihttps://doi.org/10.1242/jcs.01553
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96318
dc.identifier.wosidWOS:000226931500004
dc.issue.numero1
dc.language.isoen
dc.pagina.final37
dc.pagina.inicio27
dc.revistaJournal of cell science
dc.rightsacceso restringido
dc.subjectconnexins
dc.subjectmyoblasts
dc.subjectmyogenesis
dc.subjectregeneration
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExpression of connexins during differentiation and regeneration of skeletal muscle
dc.typeartículo
dc.volumen118
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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