Single-Cell Immunobiology of the Maternal-Fetal Interface
| dc.contributor.author | Miller, Derek | |
| dc.contributor.author | Garcia-Flores, Valeria | |
| dc.contributor.author | Romero, Roberto | |
| dc.contributor.author | Galaz, Jose | |
| dc.contributor.author | Pique-Regi, Roger | |
| dc.contributor.author | Gomez-Lopez, Nardhy | |
| dc.date.accessioned | 2025-01-20T21:01:23Z | |
| dc.date.available | 2025-01-20T21:01:23Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Pregnancy success requires constant dialogue between the mother and developing conceptus. Such crosstalk is facil-itated through complex interactions between maternal and fetal cells at distinct tissue sites, collectively termed the "maternal -fetal interface." The emergence of single-cell technologies has enabled a deeper understanding of the unique processes taking place at the maternal -fetal interface as well as the discovery of novel pathways and immune and nonimmune cell types. Single-cell approaches have also been applied to decipher the cellular dynamics through-out pregnancy, in parturition, and in obstetrical syndromes such as recurrent spontaneous abortion, preeclampsia, and preterm labor. Furthermore, single-cell technologies have been used during the recent COVID-19 pandemic to eval-uate placental viral cell entry and the impact of SARS-CoV-2 infection on maternal and fetal immunity. In this brief review, we summarize the current knowledge of cellular immunobiology in pregnancy and its complica-tions that has been generated through single-cell investi-gations of the maternal -fetal interface. The Journal of Immunology, 2022, 209: 1450-1464. | |
| dc.fuente.origen | WOS | |
| dc.identifier.doi | 10.4049/jimmunol.2200433 | |
| dc.identifier.eissn | 1550-6606 | |
| dc.identifier.issn | 0022-1767 | |
| dc.identifier.uri | https://doi.org/10.4049/jimmunol.2200433 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/92872 | |
| dc.identifier.wosid | WOS:000886067700006 | |
| dc.issue.numero | 8 | |
| dc.language.iso | en | |
| dc.pagina.final | 1464 | |
| dc.pagina.inicio | 1450 | |
| dc.revista | Journal of immunology | |
| dc.rights | acceso restringido | |
| dc.subject.ods | 03 Good Health and Well-being | |
| dc.subject.odspa | 03 Salud y bienestar | |
| dc.title | Single-Cell Immunobiology of the Maternal-Fetal Interface | |
| dc.type | artículo | |
| dc.volumen | 209 | |
| sipa.index | WOS | |
| sipa.trazabilidad | WOS;2025-01-12 |