Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study

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dc.catalogadoryvc
dc.contributor.authorJaffer, Farouc A.
dc.contributor.authorO’Donnell, Christopher J.
dc.contributor.authorLarson, Martin G.
dc.contributor.authorChan, Stephen K.
dc.contributor.authorKissinger, Kraig V.
dc.contributor.authorKupka, Michelle J.
dc.contributor.authorSalton, Carol
dc.contributor.authorBotnar, René Michael
dc.contributor.authorLevy, Daniel
dc.contributor.authorWarren J., Manning
dc.date.accessioned2025-03-04T20:46:55Z
dc.date.available2025-03-04T20:46:55Z
dc.date.issued2002
dc.description.abstractAutopsy data demonstrate a correlation between subclinical aortic atherosclerosis and cardiovascular disease. Therefore, noninvasive cardiovascular magnetic resonance (CMR) of subclinical atherosclerosis may provide a novel measure of cardiovascular risk, but it has not been applied to an asymptomatic population-based cohort to establish age- and sex-specific normative data. Participants in the Framingham Heart Study offspring cohort who were free of clinically apparent coronary disease were randomly sampled from strata of sex, quartiles of age, and quintiles of Framingham Coronary Risk Score. Subjects (n=318, aged 60±9 years, range 36 to 78 years, 51% women) underwent ECG-gated T2-weighted black-blood thoracoabdominal aortic CMR scanning. CMR evidence of aortic atherosclerosis was noted in 38% of the women and 41% of the men. Plaque prevalence and all measures of plaque burden increased with age group and were greater in the abdomen than in the thorax for both sexes and across all age groups. In addition, the Framingham Coronary Risk Score was significantly correlated with all plaque prevalence and burden measures for women but only for men after age adjustment. These noninvasive CMR data extend the prior autopsy-based prevalence estimates of subclinical atherosclerosis and may help to lay the foundation for future studies of risk stratification and treatment of affected individuals.
dc.fechaingreso.objetodigital2025-03-04
dc.fuente.origenORCID
dc.identifier.doi10.1161/01.ATV.0000012662.29622.00
dc.identifier.eissn1524-4636
dc.identifier.urihttps://doi.org/10.1161/01.ATV.0000012662.29622.00
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102354
dc.information.autorucEscuela de Ingeniería; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final854
dc.pagina.inicio849
dc.publisherLippincott Williams & Wilkins
dc.revistaArteriosclerosis, Thrombosis, and Vascular Biology
dc.rightsacceso restringido
dc.subjectMagnetic resonance imaging
dc.subjectAortas
dc.subjectAtherosclerosis
dc.subjectImaging
dc.subjectSubclinical disease
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAge and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study
dc.typeartículo
dc.volumen22
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2024-01-15
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