Mitochondrial phenotype of marsupial torpor: Fuel metabolic switch in the Chilean mouse-opossum Thylamys elegans

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dc.contributor.authorAndres Cortes, Pablo
dc.contributor.authorDaniel Bacigalupe, Leonardo
dc.contributor.authorMondaca, Fredy
dc.contributor.authorDesrosiers, Veronique
dc.contributor.authorBlier, Pierre U.
dc.date.accessioned2024-01-10T13:14:54Z
dc.date.available2024-01-10T13:14:54Z
dc.date.issued2016
dc.description.abstractTorpor is a phenotype characterized by a controlled decline of metabolic rate and body temperature. During arousal from torpor, organs undergo rapid metabolic reactivation and rewarming to near normal levels. As torpor progress, animals show a preference for fatty acids over glucose as primary source of energy. Here, we analyzed for first time the changes in the maximal activity of key enzymes related to fatty acid (Carnitine palmitoyltransferase and -Hydroxyacyl CoA dehydrogenase) and carbohydrate (Pyruvate kinase, Phosphofructokinase and Lactate dehydrogenase) catabolism, as well as mitochondrial oxidative capacity (Citrate synthase), in six organs of torpid, arousing and euthermic Chilean mouse-opossums (Thylamys elegans). Our results showed that activity of enzymes related to fatty acid and carbohydrate catabolism were different among torpor phases and the pattern of variation differs among tissues. In terms of lipid utilization, maximal enzymatic activities differ in tissues with high oxidative capacity such as heart, kidney, and liver. In terms of carbohydrate use, lower enzymatic activities were observed during torpor in brain and liver. Interestingly, citrate synthase activity did not differ thought torpor-arousal cycle in any tissues analyzed, suggesting no modulation of mitochondrial content in T. elegans. Overall results provide an indication that modulation of enzymes associated with carbohydrate and fatty-acid pathways is mainly oriented to limit energy expensive processes and sustain energy metabolism during transition from torpor to euthermy. Future studies are required to elucidate if physiological events observed for T. elegans are unique from other marsupials, or represents a general response in marsupials. (c) 2015 Wiley Periodicals, Inc.
dc.description.funderPrograma de Mejoramiento de la Calidad y la Equidad de la Educacion Superior
dc.description.funderJEB Travelling Fellowship
dc.description.funderComision Nacional de Investigacion Cientifica y Tecnologica
dc.description.funderBeca Doctoral de la Comision Nacional de Investigacion Cientifica y Tecnologica
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico
dc.description.funderNSERC Discovery Grant
dc.fechaingreso.objetodigital2024-04-27
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/jez.1994
dc.identifier.eissn2471-5646
dc.identifier.issn2471-5638
dc.identifier.pubmedidMEDLINE:26553608
dc.identifier.urihttps://doi.org/10.1002/jez.1994
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78452
dc.identifier.wosidWOS:000368727400004
dc.information.autorucCiencias Biológicas;Cortes P;S/I;181454
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final51
dc.pagina.inicio41
dc.publisherWILEY
dc.revistaJOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectMAMMALIAN HIBERNATION
dc.subjectGROUND-SQUIRRELS
dc.subjectKETONE-BODIES
dc.subjectCOLD ISCHEMIA
dc.subjectMUSCLE
dc.subjectLIVER
dc.subjectTEMPERATURE
dc.subjectAROUSAL
dc.subjectENERGY
dc.subjectBATS
dc.subject.ods15 Life on Land
dc.subject.ods13 Climate Action
dc.subject.odspa15 Vida de ecosistemas terrestres
dc.subject.odspa13 Acción por el clima
dc.titleMitochondrial phenotype of marsupial torpor: Fuel metabolic switch in the Chilean mouse-opossum Thylamys elegans
dc.typeartículo
dc.volumen325
sipa.codpersvinculados181454
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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