CHANGES IN EXTRACELLULAR LEVELS OF GLUTAMATE AND ASPARTATE IN RAT SUBSTANTIA-NIGRA INDUCED BY DOPAMINE-RECEPTOR LIGANDS - IN-VIVO MICRODIALYSIS STUDIES

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dc.contributor.authorABARCA, J
dc.contributor.authorGYSLING, K
dc.contributor.authorROTH, RH
dc.contributor.authorBUSTOS, G
dc.date.accessioned2025-01-21T01:34:59Z
dc.date.available2025-01-21T01:34:59Z
dc.date.issued1995
dc.description.abstractThe microdialysis technique was utilized to study the local effects of D-1 and D-2 family type dopamine (DA) receptor (R) ligands on the in vivo release of endogenous glutamate (GLU) and aspartate (ASP) from rat substantia nigra (SN). Addition to the dialysis perfusion solution of either D-1-R and D-2-R agonists, such as SKF-38393 (50 and 100 mu M) and Quinpirole (5 and 10 mu M), resulted in dose-dependent increases in extracellular concentrations of GLU and ASP, respectively. The SKF-38393 and Quinpirole-induced effects were reduced by SCH-23390 (0.5 mu M), a D-1-R antagonist, and by Spiperone (1.0 mu M), a D-2-R antagonist, respectively. However, SCH-23390 and Spiperone did increase GLU and ASP extracellular concentrations. Local infusion with Tetrodotoxin (TTX) (1.0 mu M), a blocker of voltage-dependent Na+ channels, increased basal extracellular levels of GLU. In addition, co-infusion of TTX and SKF-38393 evoked increases in extracellular GLU levels higher than those observed after SKF-38393 alone. Finally, chemical lesions of nigral DA cells with 6-OH-DA. increased the basal extracellular levels of GLU. It is proposed that the release of GLU and ASP from SN may be regulated by D-1- and D-2- receptors present in this basal ganglia structure. In addition, part of the D-1 receptors present in SN might be located presynaptically on GLU-containing nerve endings.
dc.description.funderNIMH NIH HHS
dc.fuente.origenWOS
dc.identifier.issn0364-3190
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97626
dc.identifier.wosidWOS:A1995QQ04400007
dc.issue.numero2
dc.language.isoen
dc.pagina.final169
dc.pagina.inicio159
dc.revistaNeurochemical research
dc.rightsacceso restringido
dc.subjectSUBSTANTIA NIGRA
dc.subjectDOPAMINE RECEPTORS
dc.subjectGLUTAMATE
dc.subjectASPARTATE
dc.subjectIN VIVO RELEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCHANGES IN EXTRACELLULAR LEVELS OF GLUTAMATE AND ASPARTATE IN RAT SUBSTANTIA-NIGRA INDUCED BY DOPAMINE-RECEPTOR LIGANDS - IN-VIVO MICRODIALYSIS STUDIES
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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