The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

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dc.article.number8184
dc.article.number8184
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dc.contributor.authorThorell, Kaisa
dc.contributor.authorMuñoz-Ramírez, Zilia Y.
dc.contributor.authorWang, Difei
dc.contributor.authorSandoval-Motta, Santiago
dc.contributor.authorBoscolo Agostini, Rajiv
dc.contributor.authorGhirotto, Silvia
dc.contributor.authorTorres, Roberto C.
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dc.contributor.authorQuilty D.
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorSerrano Honeyman, Carolina
dc.contributor.authorGonzález Donoso, Robinson
dc.contributor.authorRiquelme Pérez, Arnoldo
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dc.contributor.authorTarazona-Santos E.
dc.contributor.authorMarino-Ramirez L.
dc.contributor.authorLoh J.T.
dc.contributor.authorBackert S.
dc.contributor.authorNaumann M.
dc.contributor.authorAbnet C.C.
dc.contributor.authorSmet A.
dc.contributor.authorBerg D.E.
dc.contributor.authorChiner-Oms A.
dc.contributor.authorComas I.
dc.contributor.authorMartinez-Martinez F.J.
dc.contributor.authorZamudio R.
dc.contributor.authorLehours P.
dc.contributor.authorMegraud F.
dc.contributor.authorYahara K.
dc.contributor.authorBlaser M.J.
dc.contributor.authorVincze T.
dc.contributor.authorMorgan R.D.
dc.contributor.authorRoberts R.J.
dc.contributor.authorChanock S.J.
dc.contributor.authorDekker J.P.
dc.contributor.authorTorres J.
dc.contributor.authorCover T.L.
dc.contributor.authorNoureen M.
dc.contributor.authorFischer W.
dc.contributor.authorVale F.F.
dc.contributor.authorCherry J.L.
dc.contributor.authorOsada N.
dc.contributor.authorFukuyo M.
dc.contributor.authorArita M.
dc.contributor.authorYamaoka Y.
dc.contributor.authorKobayashi I.
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dc.date.accessioned2025-11-27T13:08:17Z
dc.date.available2025-11-27T13:08:17Z
dc.date.issued2023
dc.description.abstractHelicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
dc.description.funderCONICYT-FONDAP
dc.description.funderChilean National Fund for Health Research and Development
dc.description.funderDECIT
dc.description.funderDepartamento de Ciência e Tecnologia
dc.description.funderDivision of Logistic Services
dc.description.funderFONIS
dc.description.funderFrench Association pour la Recherche Contre le Cancer
dc.description.funderGreek Ministry of Culture and Education
dc.description.funderHellenic Helicobacter pylori Study Group
dc.description.funderHorizon 2020 Programme of European Union
dc.description.funderHospital Clínica Bíblica
dc.description.funderInstituto Nacional de Enfermedades Neoplasicas
dc.description.funderJapanese National Institutes of Health
dc.description.funderKyrgyz State Medical Academy
dc.description.funderMinistry of Health for Institutional Research
dc.description.funderMinistry of Higher Education Science and Technology of the Dominican Republic
dc.description.funderMinistry of Science and Technology, Executive Yuan, Taiwan
dc.description.funderNational Cancer Center of South Korea
dc.description.funderNational Cancer Institute’s Division of Cancer Epidemiology
dc.description.funderNational Fund for Innovation and Development of Science and Technology
dc.description.funderNational Multicenter Laboratory Surveillance Studies
dc.description.funderNational Strategic Reference Framework Operational Program “Competitiveness, Entrepreneurship and Innovation
dc.description.funderUniversity of Malaya-Ministry of Higher Education
dc.description.funderUniversity of Puerto Rico Comprehensive Cancer Center
dc.description.funderNational Institutes of Health
dc.description.funderNCI
dc.description.funderUS National Institute of Allergy and Infectious Diseases
dc.description.funderUS National Library of Medicine
dc.description.funderUS National Institute on Minority Health and Health Disparities
dc.description.funderMinistry of Science and Technology of Vietnam
dc.description.funderMinistry of Health
dc.description.funderUniversidad Científica del Sur
dc.description.funderArcticNet
dc.description.funderCanadian Institutes for Health Research
dc.description.funderAlberta Innovates Health Solutions
dc.description.funderNational Medical Research Council
dc.description.funderSingapore Ministry of Health
dc.description.funderNational Research Foundation of Singapore
dc.description.funderJapanese Ministry of Education, Culture, Sports, Science, and Technology
dc.description.funderFundação de Amparo à Pesquisa do Estado de São Paulo
dc.description.funderGerman Federal Ministry of Education and Research
dc.description.funderFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.funderCNPq
dc.description.funderSwedish Society for Medical Research
dc.description.funderSwedish Research Council
dc.description.funderNetwork of Centres of Excellence of Canada
dc.description.funderAssar Gabrielsson Foundation
dc.description.funderUniversidad de Costa Rica
dc.description.funderMagnus Bergvall Foundation
dc.description.funderInstitut National du Cancer
dc.description.funderCanceropole Grand Sud-Ouest
dc.description.funderHellenic Society of Gastroenterology
dc.fechaingreso.objetodigital2025-11-27
dc.format.extent16 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1038/s41467-023-43562-y
dc.identifier.eissn2041-1723
dc.identifier.scopusidSCOPUS_ID:85179650185
dc.identifier.urihttps://doi.org/10.1038/s41467-023-43562-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107145
dc.information.autorucEscuela de Medicina; Corvalán R., Alejandro; 0000-0001-5492-3853; 63885
dc.information.autorucFacultad de Ciencias Biológicas; Serrano Honeyman, Carolina; 0000-0001-5523-0637; 15296
dc.information.autorucEscuela de Medicina; González Donoso, Robinson; S/I; 74594
dc.information.autorucEscuela de Medicina; Riquelme Pérez, Arnoldo; 0000-0002-8259-8960; 3538
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherNature Research
dc.revistaNature Communications
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc570
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
dc.typeartículo
dc.volumen14
sipa.codpersvinculados63885
sipa.codpersvinculados15296
sipa.codpersvinculados74594
sipa.codpersvinculados3538
sipa.trazabilidadSCOPUS;2023-12-24
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