Age does not affect the outcome of allogeneic hematopoietic precursor transplantation for acute myeloid leukemiaResultados a largo plazo de una cohorte chilena: La edad del paciente no incide en el resultado del trasplante alogénico de precursores hematopoyéticos para leucemia mieloide aguda

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dc.contributor.authorSarmiento M.
dc.contributor.authorRojas P.
dc.contributor.authorTriantafilo N.
dc.contributor.authorCampbell J.
dc.contributor.authorGarcía M.J.
dc.contributor.authorOcqueteau M.
dc.contributor.authorSandoval V.
dc.contributor.authorRojas A.
dc.contributor.authorGazmuri J.T.
dc.contributor.authorGuerrero G.
dc.contributor.authorVergara M.
dc.contributor.authorBertin P.
dc.contributor.authorRamírez P.
dc.contributor.authorJara V.
dc.contributor.authorGutiérrez C.
dc.contributor.authorSoto K.
dc.contributor.authorArellano S.
dc.contributor.authorPizarro I.
dc.contributor.authorLorca C.
dc.contributor.authorRivera E.
dc.contributor.authorÁlvarez E.
dc.contributor.authorValdés M.
dc.contributor.authorPereira J.
dc.contributor.authorBarriga F.
dc.date.accessioned2025-05-01T10:30:15Z
dc.date.available2025-05-01T10:30:15Z
dc.date.issued2021
dc.description.abstract© 2021 Sociedad Medica de Santiago. All rights reserved.Background: In our country, transplantation centers differ in the age limit for allogeneic hematopoietic transplantation (ALOHT). In our program, transplants with age- adjusted conditioning are performed in patients until 70 years old. Currently more than 60% of ALOHT reported to the Center for International Bone Marrow Transplantation Research (CIBMTR) are performed in patients older than 40 years. Aim: To report our experience with ALOHT in acute myelogenous leukemia (AML), analyzing patient age at transplantation in different periods and transplant results in different age groups. Material and Methods: A retrospective analysis of the database of adult hematopoietic transplants in AML patients was performed. Demographic data, disease characteristics, transplant data, survival and relapse times, and mortality were collected. Results: In our program, 1030 transplants were performed in adults and 119 ALOHT were performed in AML patients, between 1990 and 2020. The median age of patients in all periods was 41 years, (range 16-69). The median age was 33 and 45 years, in the periods 1990-2000 and 2000-2020 respectively (p < 0.01). Seventy-eight patients received myeloablative conditioning (median age 44 years) and 41 reduced intensity conditioning (median age 53 years). Five-year overall survival was 44.6% (confidence intervals (CI) 41-48). Non relapse mortality of all periods was 19% (CI 17 - 40%) and relapse rate was 17 % (CI 16-22). No difference in five years overall survival among patients younger than 40, 41 to 50 and over 51 years was observed. Conclusions: Overall Survival, non-relapse mortality and relapse rate were similar in younger and older patients in our program and similar to those previously reported in other centers.
dc.description.funderANID
dc.description.funderSergio San Mart?n
dc.description.funderFONDECYT
dc.format.extent10 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/S0034-98872021000100022
dc.identifier.eissn07176163
dc.identifier.issn07176163 00349887
dc.identifier.pubmedid34106132
dc.identifier.scieloidS0716-27902024000100135
dc.identifier.scopusidSCOPUS_ID:85106902975
dc.identifier.urihttps://doi.org/10.4067/S0034-98872021000100022
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103607
dc.identifier.wosidWOS:000613501500006
dc.information.autorucEscuela de Medicina; Sarmiento Maldonado Mauricio; 0000-0003-3715-9886; 167160
dc.information.autorucEscuela de Medicina; Pereira Garces Jaime Ignacio; 0000-0003-0481-328X; 99371
dc.information.autorucEscuela de Medicina; Ocqueteau Tacchini Mauricio Esteban; S/I; 71377
dc.information.autorucEscuela de Medicina; Rojas Reyes Patricio Andres; S/I; 149909
dc.information.autorucEscuela de Medicina; Campbell Wagemann James Michael; S/I; 179250
dc.information.autorucEscuela de Medicina; Bertin Cortes-monroy Pablo Alfonso; 0000-0002-1663-8848; 99372
dc.issue.numeroCD011973
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final29
dc.pagina.inicio22
dc.relation.ispartof16th International Vasculitis & ANCA Workshop
dc.revistaRevista Medica de Chile
dc.rightsAcceso abierto
dc.subjectLeukemia
dc.subjectSurvival
dc.subjectTransplantation, Homologous
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAge does not affect the outcome of allogeneic hematopoietic precursor transplantation for acute myeloid leukemiaResultados a largo plazo de una cohorte chilena: La edad del paciente no incide en el resultado del trasplante alogénico de precursores hematopoyéticos para leucemia mieloide aguda
dc.typeartículo
dc.volumen149
sipa.codpersvinculados167160
sipa.codpersvinculados99371
sipa.codpersvinculados71377
sipa.codpersvinculados149909
sipa.codpersvinculados179250
sipa.codpersvinculados99372
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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